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Meta-analysis to follow-up genome-wide association study in scizophrenia

Research Project

Project/Area Number 23591683
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNihon University

Principal Investigator

TAKAHASHI Sakae  日本大学, 医学部, 准教授 (70297802)

Co-Investigator(Kenkyū-buntansha) UCHIYAMA Makoto  日本大学, 医学部, 教授 (20221111)
AKIYAMA Mayumi  日本大学, 医学部, 助教 (50386017)
YOKOSE Hiromi  日本大学, 医学部, 助手 (40465274)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords統合失調症 / ゲノムワイド相関研究 / 原因遺伝子 / 精神医学 / 遺伝学 / 分子遺伝学
Research Abstract

We have finished genotyping 12 Single Nucleotide Polymorphisms (SNPs)in 536 schizophrenic families (1633 members including 699 schizophrenics). These SNPs were important in previous genome-wide association study (GWAS). As a result, two genes were significantly associated with schizophrenia. We are submitting the results to a major English journal.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (2 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Abdominal paresthesia resembling restless legs syndrome successfully treated with iron supplement : A case report2014

    • Author(s)
      Suzuki M, Yamada K, Kanamori T, Konno C, Konno M, Takahashi S, Aramaki O, Takayama T, Uchiyama M
    • Journal Title

      J Neurol Sci

      Volume: 336 Pages: 291-292

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of Schizopherenia : Genetic and Symptomatic Factors2013

    • Author(s)
      Takahashi S
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

      Volume: 162 B Pages: 648-652

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden2013

    • Author(s)
      Takahashi S, Suzuki M, Uchiyama M
    • Journal Title

      J Neuropsychiatry Clin Neurosci

      Volume: 25

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-year follow-up study of psychotic patients treated with blonanserin : A case series2013

    • Author(s)
      Takahashi S, Suzuki M, Uchiyama M
    • Journal Title

      ASIA-PACIFIC PSYCHIATRY

      Volume: 5 Pages: 164-167

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association between sleep problems and perceived health status : A Japanese nationwide general population survey2013

    • Author(s)
      Furihata R, Uchiyama M, Takahashi S, Suzuki M, Konno C, Osaki K, Konno M, Kaneita Y, Ohida T, Akahoshi T, Hashimoto Shu, Akashiba T
    • Journal Title

      Sleep Medicine

      Volume: 13 Pages: 831-837

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity of Schizopherenia: Genetic and Symptomatic Factors.2013

    • Author(s)
      Takahashi S
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

      Volume: 162 Pages: 648-652

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden.2013

    • Author(s)
      Takahashi S, Suzuki M, Uchiyama M
    • Journal Title

      J Neuropsychiatry Clin Neurosci

      Volume: 25 Pages: 28-28

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-year follow-up study of psychotic patients treated with blonanserin: A case series.2013

    • Author(s)
      Takahashi S, Suzuki M, Uchiyama M
    • Journal Title

      ASIA-PACIFIC PSYCHIATRY

      Volume: 5 Pages: 164-167

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between sleep problems and perceived health status: A Japanese nationwide general population survey2013

    • Author(s)
      Furihata R, Takahashi S, et al.
    • Journal Title

      Sleep Medicine

      Volume: 13 Pages: 831-837

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationships between exploratory eye movement dysfunction and clinical symptoms in schizophrenia2012

    • Author(s)
      Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Otsuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 66 Pages: 187-194

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 「近年における精神医学の進歩―生物学的な側面から」統合失調症2012

    • Author(s)
      高橋栄
    • Journal Title

      日大医学雑誌

      Volume: 71 Pages: 369-374

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Case history and genome-wide scans for copy number variants (CNVs) in a family with 22q11.2 deletion syndrome (22q11.2DS)2013

    • Author(s)
      Nakamura S, Takahashi S, Suzuki T, Oosaki K, Soutome Y, Nagai K, Sagawa T, Uchiyama M
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] 22番染色体欠失症候群(22q11.2DS)家系の長期経過観察と全ゲノムcopy number variants(CNVs)解析2012

    • Author(s)
      中村桜子, 高橋栄, 鈴木貴浩, 大嵜公一, 早乙女優太, 佐川倫啓, 鈴木正泰, 内山真
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Book] メンタル医療―原因解明と診断, 治療の最前線―. 精神疾患における診断機器応用の可能性2013

    • Author(s)
      高橋栄 (糸川昌成監修)
    • Publisher
      シーエムシー出版,東京
    • Related Report
      2013 Final Research Report
  • [Book] 精神疾患診断のための脳形態・機能検査法.探索眼球運動による統合失調症の診断2012

    • Author(s)
      高橋栄, 鈴木正泰, 内山真, 小島卓也 (三國雅彦・福田正人・功刀浩編著)
    • Publisher
      新興医学出版社, 東京
    • Related Report
      2013 Final Research Report
  • [Remarks] 8. 小島卓也, 松島英介, 高橋栄, 安藤克巳 : 脳科学辞典(加藤忠志 編集). 探索眼球運動, Web, 2013

    • URL

      http://bsd.neuroinf.jp

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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