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Framing a biomaker of prodromal schizophrenia by magnetoencephalography

Research Project

Project/Area Number 23591713
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

MAEKAWA Toshihiko  九州大学, 医学(系)研究科(研究院), 助教 (40448436)

Co-Investigator(Kenkyū-buntansha) ONITSUKA Toshiaki  九州大学, 大学病院, 講師 (00398059)
Co-Investigator(Renkei-kenkyūsha) KANBA Shigenobu   (50195187)
TOBIMATSU Shozo   (40164008)
HIRANO Yoji   (90567497)
HIRANO Shogo   (10568984)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords初発統合失調症 / 脳磁図 / 視覚情報処理 / ミスマッチ陰性電位 / バイオマーカー / ウインドミル / ウインドミル視覚刺激
Research Abstract

Schizophrenia is often decided by its clinical course and peculiar symptom without biological markers. In this study, automatic brain magnetic response from a visual task in patients with first episode schizophrenia and chronic schizophrenia were tested. In summary, there were no difference of the responses between in first episode schizophrenia and healthy control. However, the response in patients with chronic schizophrenia was declined. Therefore, the brain function of schizophrenia can be estimated objectively by measuring brain magnetic response during our visual task.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (48 results)

All 2014 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 15 results) Presentation (20 results) Book (11 results)

  • [Journal Article] Preattentive dysfunction in patients with bipolar disorder as revealed by the pitch-mismatch negativity: an MEG study2014

    • Author(s)
      Katsuki S, Onitsuka T, Oribe N, Maekawa T, Tsuchimoto R, Hirano S, Ueno T, Hirano Y, Miura T, Kanba S
    • Journal Title

      Bipolar Disorders

      Volume: 印刷中 Pages: 1-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自閉症スペクトラムにおける視覚「ブロップ障害仮説」の脳内基盤の検証:事象関連電位を用いた研究2014

    • Author(s)
      山崎貴男,前川敏彦,宮永幸佳,飛松省三
    • Journal Title

      発達研究

      Volume: 24 Pages: 181-188

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered visual information processing systems in bipolar disorder : evidence from visual MMN and P32013

    • Author(s)
      Maekawa T, Katsuki S, Kishimoto J, Onitsuka T, Ogata K, Yamasaki T, Ueno T, Tobimatsu S, Kanba S
    • Journal Title

      Front Hum Neurosci

      Volume: 7 Pages: 403-403

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症の視覚ミスマッチ脳磁場反応2013

    • Author(s)
      前川敏彦,中村一太,小原尚利,小田祐子,鬼塚俊明,浦川智和,飛松省三,神庭重信
    • Journal Title

      第28回日本生体磁気学会大会論文集

      Pages: 112-113

    • URL

      http://www.nips.ac.jp/smf/JBBS/ronbun.html

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] サブリミナル顔刺激を用いたアスペルガー症候群の情動刺激処理の解明2013

    • Author(s)
      前川敏彦,黒木俊秀,飛松省三
    • Journal Title

      明治安田こころの健康財団研究助成論文集

      Volume: 48 Pages: 98-114

    • URL

      http://www.my-kokoro.jp/kokoro/books/contents/item_10.php

    • Related Report
      2013 Final Research Report
  • [Journal Article] Rapid maturation of voice and linguistic processing systems in preschool children: A near-infrared spectroscopic study2013

    • Author(s)
      Yamasaki, T., Ogata, K., Maekawa, T., Ijichi, I., Katagiri, M., Mitsudo, T., Kamio, Y., Tobimatsu, S.
    • Journal Title

      Experimental Neurology

      Volume: 250 Pages: 313-320

    • DOI

      10.1016/j.expneurol.2013.10.005

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered visual information processing systems in bipolar disorder: evidence from visual MMN and P32013

    • Author(s)
      Maekawa T, Katsuki S, Kishimoto J, Onitsuka T, Ogata K, Yamasaki T, Ueno T, Tobimatsu S, Kanba S
    • Journal Title

      Front Hum Neurosci

      Volume: 7 Pages: 403-403

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auditory and visual mismatch negativity in psychiatric disorders: a review2012

    • Author(s)
      Maekawa T, Hirano S, Onitsuka T
    • Journal Title

      Current Psychiatry Reviews

      Volume: 8 Issue: 2 Pages: 97-105

    • DOI

      10.2174/1573400511208020097

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered face inversion effect and association between face N170 reduction and social dysfunction in patients with schizophrenia2012

    • Author(s)
      Tsunoda T, et al
    • Journal Title

      Clinical Neurophysiology

      Volume: (In press) Issue: 9 Pages: 1762-1768

    • DOI

      10.1016/j.clinph.2012.01.024

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Visual mismatch negativity in psychiatric disorders2012

    • Author(s)
      Maekawa T, Onitsuka T, Tobimatsu S
    • Journal Title

      Int J Psychophysiol

      Volume: 85 Issue: 3 Pages: 324-324

    • DOI

      10.1016/j.ijpsycho.2012.06.095

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Longitudinal study of sensory information processing in schizophrenia using whole head 306-ch magnetoencephalography2012

    • Author(s)
      Maekawa T
    • Journal Title

      The Report of Study Result by Subsidy, Magnetic Health Science Foundation

      Pages: 34-36

    • URL

      http://www.maghealth.or.jp/file/houkokusyo_japanese2010.pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients2012

    • Author(s)
      Oda Y, Onitsuka T, Tsuchimoto R, et al
    • Journal Title

      PLoS ONE

      Volume: 7(7)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Auditory and visual mismatch negativity in psychiatric disorders: a review2012

    • Author(s)
      Toshihiko Maekawa, Shogo Hirano, Toshiaki Onitsuka
    • Journal Title

      Current Psychiatry Reviews

      Volume: 8 Pages: 97-105

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Auditory and visusal mismatch negativity in psychiatric disorders: A review2012

    • Author(s)
      Toshihiko Maekwa, Shogo Hirano, Toshiaki Onitsuka
    • Journal Title

      Current Psychiatry Reviews

      Volume: 8 Pages: 97-105

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Top-down and bottom-up visual information processing of non-social stimuli in high-functioning autism spectrum disorder2011

    • Author(s)
      Maekawa, et al
    • Journal Title

      Res Autism Spectr Disord

      Volume: 5 Issue: 1 Pages: 201-209

    • DOI

      10.1016/j.rasd.2010.03.012

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia2011

    • Author(s)
      Tsuchimoto R, Kanba S, Hirano S, et al
    • Journal Title

      Schizophr Res

      Volume: 133 Issue: 1-3 Pages: 99-105

    • DOI

      10.1016/j.schres.2011.07.020

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Top-down and bottom-up viusal information processing of non-social stimuli in high-functioning autism spectrum disorder2011

    • Author(s)
      Toshihiko Maekawa, Shozo Tobimatsu, Naoko Inada, Naoya Oribe, Toshiaki Onitsuka, Shigenobu Kanba, Yoko Kamio
    • Journal Title

      Research in autism spectrum disorders

      Volume: 5 Pages: 201-209

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Altered visual predictive systems in bipolar disorder : evidence from visual MMN and P3002013

    • Author(s)
      Maekawa T, Tobimatsu S, Kanba S
    • Organizer
      2013 Asian and Oceanian Congress of Clinical Neurophysiology
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2013-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 統合失調症の視覚ミスマッチ誘発磁場反応2013

    • Author(s)
      前川敏彦,中村一太,小原尚利,小田祐子,鬼塚俊明,浦川智和,飛松省三,神庭重信
    • Organizer
      第28回日本生体磁気学会
    • Place of Presentation
      新潟市
    • Year and Date
      2013-06-08
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 双極性障害の視覚予期システム異常 : 視覚ミスマッチ陰性電位とP300研究2013

    • Author(s)
      勝木聡美,前川敏彦,鬼塚俊明,飛松省三,神庭重信
    • Organizer
      第10回日本うつ病学会
    • Place of Presentation
      北九州市
    • Year and Date
      2013-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 事象関連電位概説2013

    • Author(s)
      前川敏彦
    • Organizer
      第464回福岡臨床と脳波懇話会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-05-15
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] ltered visual predictive systems in bipolar disorder: evidence from visual MMN and P3002013

    • Author(s)
      Maekawa T, Tobimatsu S, Kanba S
    • Organizer
      Asian and Oceanian Congress of Clinical Neurophysiology
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2013 Annual Research Report
  • [Presentation] 初老期女性うつ病のピットホール2013

    • Author(s)
      前川敏彦
    • Organizer
      筑後地区医師会学術講演会
    • Place of Presentation
      久留米市
    • Related Report
      2013 Annual Research Report
  • [Presentation] レベチラセタム投与後に易刺激性が出現した外傷後てんかん2013

    • Author(s)
      前川敏彦
    • Organizer
      第212回福岡てんかん懇話会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抑うつ症状を主訴に受診した高齢発症側頭葉てんかん2013

    • Author(s)
      前川敏彦,鬼塚俊明,中村一太,小原尚利,佐藤仁哉,勝木聡美,磯村周一
    • Organizer
      第8回日本てんかん学会九州地方会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 双極性障害の視覚予期システム異常:視覚ミスマッチ陰性電位とP300研究2013

    • Author(s)
      前川敏彦,勝木聡美,鬼塚俊明,飛松省三,神庭重信
    • Organizer
      第10回日本うつ病学会
    • Place of Presentation
      北九州市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 従来薬からレベチラセタムへのスイッチングの考察2013

    • Author(s)
      前川敏彦
    • Organizer
      EKeppra Mini-Forum久留米
    • Place of Presentation
      久留米市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 九州大学病院精神科外来てんかん患者の運転免許に関する調査報告2013

    • Author(s)
      前川敏彦,鬼塚俊明,中村一太,小原尚利,小田祐子,土本利架子,勝木聡美,神庭重信
    • Organizer
      第47回日本てんかん学会
    • Place of Presentation
      北九州市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 「回転する蛇」錯視に対する神経磁場活動の時間周波数解析2012

    • Author(s)
      前川敏彦,浦川智和,廣永成人,緒方勝也,飛松省三
    • Organizer
      第41回日本臨床神経生理学会
    • Place of Presentation
      東京都
    • Year and Date
      2012-11-09
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 統合失調症の視覚ミスマッチ脳磁場の検討 : MEG研究2012

    • Author(s)
      前川敏彦,鬼塚俊明,中村一太,小田祐子,小原尚利,勝木聡美,神庭重信
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸市
    • Year and Date
      2012-09-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Visual mismatch negativity in psychiatric disorders2012

    • Author(s)
      Maekawa T
    • Organizer
      The 16th World Congress of Psychophysiology of the International Organization of Psychophysiology
    • Place of Presentation
      Pisa, Italy (Symposium)
    • Year and Date
      2012-09-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 「回転する蛇」錯視に関与する神経オシレーション2012

    • Author(s)
      竹田功昴,浦川智和,前川敏彦,廣永成人,緒方勝也,飛松省三
    • Organizer
      第24回臨床神経生理研究会
    • Place of Presentation
      熊本市
    • Year and Date
      2012-08-25
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 「回転する蛇」錯視に関与する神経オシレーション2012

    • Author(s)
      前川敏彦,浦川智和,廣永成人,緒方勝也,飛松省三
    • Organizer
      神経オシレーション研究会
    • Place of Presentation
      岡崎市
    • Year and Date
      2012-07-12
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Visual mismatch negativity in psychiatric disorders2012

    • Author(s)
      Tsohihiko Maekawa
    • Organizer
      The 16th World Congress of Psychophysiology of the International Organization of Psychophysiology
    • Place of Presentation
      ピサ市イタリア国
    • Related Report
      2012 Research-status Report
  • [Presentation] 統合失調症の視覚ミスマッチ脳磁場の検討:MEG研究2012

    • Author(s)
      前川敏彦,鬼塚俊明,中村一太, 小田祐子,小原尚利,勝木聡美, 神庭重信
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Research-status Report
  • [Presentation] 初発統合失調症の多モダリティーERPs : Boston CIDAR Projectの中間報告2011

    • Author(s)
      前川敏彦,Margaret A. Niznikiewicz, Robert W. McCarley
    • Organizer
      第41回日本臨床神経生理学会学術大会
    • Place of Presentation
      静岡市
    • Year and Date
      2011-11-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 初発統合失調症の多モダリティーERPs:Boston CIDAR Projectの中間報告

    • Author(s)
      前川敏彦、Margaret A. Niznikiewicz, Robert W. McCaley
    • Organizer
      第41回日本臨床神経生理学会学術大会
    • Place of Presentation
      静岡市
    • Related Report
      2011 Research-status Report
  • [Book] ミスマッチ陰性電位:臨床応用.モノグラフ脳機能計測法を基礎から学ぶ人のために2013

    • Author(s)
      前川敏彦 (日本臨床神経生理学会認定委員会編)
    • Publisher
      (東京都)
    • Related Report
      2013 Final Research Report
  • [Book] EEG(誘発電位,脳電図を含む).脳画像でみる精神疾患2013

    • Author(s)
      前川敏彦,鬼塚俊明 (山内俊雄,松田博史編)
    • Publisher
      新興医学出版社,東京都
    • Related Report
      2013 Final Research Report
  • [Book] モノグラフ 脳機能計測法を基礎から学ぶ人のために2013

    • Author(s)
      前川敏彦
    • Total Pages
      207
    • Publisher
      日本臨床神経生理学会
    • Related Report
      2013 Annual Research Report
  • [Book] 脳画像でみる精神疾患2013

    • Author(s)
      前川敏彦,鬼塚俊明
    • Total Pages
      247
    • Publisher
      新興医学出版社
    • Related Report
      2013 Annual Research Report
  • [Book] 第28回日本生体磁気学会大会論文集2013

    • Author(s)
      前川敏彦,中村一太,小原尚利,小田祐子,鬼塚俊明,浦川智和,飛松省三,神庭重信
    • Total Pages
      301
    • Publisher
      日本生体磁気学会
    • Related Report
      2013 Annual Research Report
  • [Book] 明治安田こころの健康財団研究助成論文集2013

    • Author(s)
      前川敏彦,黒木俊秀,飛松省三
    • Total Pages
      184
    • Publisher
      明治安田こころの健康財団
    • Related Report
      2013 Annual Research Report
  • [Book] 平成22年度助成研究成果報告書2012

    • Author(s)
      前川敏彦
    • Total Pages
      4
    • Publisher
      磁気健康科学研究振興財団
    • Related Report
      2012 Research-status Report
  • [Book] The Report of Study Result by Subsidy 20102012

    • Author(s)
      Toshihiko Maekawa
    • Total Pages
      4
    • Publisher
      Magnetic Health Science Foundation
    • Related Report
      2012 Research-status Report
  • [Book] 脳画像と精神疾患2012

    • Author(s)
      前川敏彦,鬼塚俊明
    • Total Pages
      12
    • Publisher
      新興医学出版社
    • Related Report
      2012 Research-status Report
  • [Book] The Comprehensive Guide to Autism2012

    • Author(s)
      Takao Yamasaki, Hidetoshi Takahashi, Takako Fujita, Yoko Kamio, Shozo Tobimatsu, Toshihiko Maekawa
    • Total Pages
      10
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report
  • [Book] Electrophysiology o autism spectrum disorders. Comprehensive guide to autism

    • Author(s)
      Yamasaki T, Maekawa T, Takahashi H, Fujita T, Kamio Y, Tobimatsu S (Colin R. Martin, Victor R. Preedy, Vinood B. Patel (Eds.))
    • Publisher
      Springer, New York
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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