An investigation of neural mechanism of early stage of solvent abuse

• Project/Area Number: 23591725
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: FUKUI Kenji 京都府立医科大学, 医学(系)研究科(研究院), 教授 (50165263)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 有機溶剤 / MRI / 有機溶剤乱用 / 神経画像

Research Abstract

This study sought to investigate neural mechanism of formation and maintenance of solvent abuse. We reported a case of solvent abuse who revealed hypofrontality shown by SPECT and frontal dysfunction on neuropsychological tests. We also measured brain activity during reward task using fMRI. We first collected data from healthy subjects to compare with patients. Moreover, we developed new cognitive task that can test performance of patients to relate past experience with current decision making and collected data from normal subjects. These tasks are expected to contribute to reveal the brain mechanism of formation and maintenance of solvent abuse.

Research Products

• [Journal Article] A tract-based spatial statistics study in anorexia nervosa : abnormality in the fornix and the cerebellum (2014)
  • Author(s): Nagahara Y, Fukui K(他10人)
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 51 Pages: 72-7
  • DOI: 10.1016/j.pnpbp.2014.01.009
  • Peer Reviewed
• [Journal Article] Voxel-based Morphometry Multi-center Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. (2014)
  • Author(s): de Wit SJ, Narumoto J, et al.
  • Journal Title: Am J Psychiatry Volume: 171 Issue: 3 Pages: 340-349
  • DOI: 10.1176/appi.ajp.2013.13040574
  • Peer Reviewed
• [Journal Article] Reduced Dorsolateral Prefrontal Cortex Hemodynamic Response in Adult Obsessive-Compulsive Disorder as Measured by Near-Infrared Spectroscopy during the verbal fluency task. (2013)
  • Author(s): Hirosawa R, Narumoto J, Sakai Y, Nishida S, Ishida T, Nakamae T, Takei Y, Fukui K.
  • Journal Title: Neuropsychiatr Dis Treat. Volume: 9 Pages: 955-962
  • DOI: 10.2147/ndt.s45402
  • Peer Reviewed
• [Journal Article] 3. 【精神科領域における最新のMRIの進歩】安静時fMRI 精神科臨床研究への応用． (2013)
  • Author(s): 酒井雄希、成本 迅、中前 貴、福居顯二
  • Journal Title: 精神科 Volume: 22 Pages: 130-137
• [Journal Article] アルコール・物質依存 (2012)
  • Author(s): 土田英人,西村伊三男,福居顯二
  • Journal Title: Brain and Nerve Volume: 64(2) Pages: 163-173
  • URL: http://medicalfinder.jp/ejournal/1416101121.html
• [Journal Article] Reduced cortical thickness in non-medicated patients with obsessive-compulsive disorder (2012)
  • Author(s): Nakamae T, Narumoto J, Sakai Y, Nishida S, Yamada K, Kubota M, Miyata J, Fukui K
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 37(1) Issue: 1 Pages: 90-5
  • DOI: 10.1016/j.pnpbp.2012.01.001
  • Peer Reviewed
• [Journal Article] 特集：生物学的精神医学の進歩．アルコール・物質依存． (2012)
  • Author(s): 土田英人，西村伊三男，福居顯二．
  • Journal Title: BRAIN and NERVE Volume: 64 Pages: 163-173
• [Presentation] Neural substrates for altered reward prediction in psychiatric disorders with serotonergic dysfunction (2013)
  • Author(s): Sakai Y, Tanaka S, Nishida S, Nakamae T, Yamada K, Doya K, Fukui K, Narumoto J
  • Organizer: International symposium on Prediction and Decision Making
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2013-10-12
• [Presentation] 脱抑制症状に有機溶剤乱用の影響が疑われた一例 (2013)
  • Author(s): 南澤淳美,駒喜多由紀,阿部能成,稲光仁志,松岡照之,岡村愛子,小川真由,成本迅,福居顯二
  • Organizer: 第113回近畿精神神経学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-07-27
• [Presentation] Altered Striatal Functional Specialization for Reward Prediction in non-medicated patients with Obsessive-Compulsive Disorder. (2013)
  • Author(s): Sakai Y, Narumoto J, Tanaka S, Nishida S, Nakamae T, Yamada K, Doya K, Fukui K.
  • Organizer: The 4th World Congress of Asian Psychiatry
  • Place of Presentation: タイ、バンコク
• [Presentation] セロトニン神経系の障害をともなう精神疾患における意思決定神経基盤 (2012)
  • Author(s): 酒井雄希,成本迅,田中沙織,西田誠司,中前貴,山田惠,銅谷賢治,福居顯二
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-28
• [Presentation] 金銭報酬を用いた異時点間の選択問題において、腹側線条体は短期の報酬予測、背側線条体は長期の報酬予測に関係した (2011)
  • Author(s): 酒井雄希,成本迅,田中沙織,西田誠司,中前貴,山田惠,銅谷賢治,福居顯二
  • Organizer: 平成23年度生理研研究会「今、社会神経科学研究に求められていること」
  • Place of Presentation: 岡崎市
  • Year and Date: 2011-10-06
• [Presentation] 金銭報酬を用いた異時点間の選択問題において、腹側線条体は短期の報酬予測、背側線条体は長期の報酬予測に関係した． (2011)
  • Author(s): 酒井雄希，成本 迅，田中沙織，西田誠司，中前 貴，山田 惠，銅谷賢治，福居顯二．
  • Organizer: 平成23年度生理研研究会｢今、社会神経科学研究に求められていること｣
  • Place of Presentation: 岡崎市
• [Book] 「依存症・衝動制御障害の治療」(専門医のための精神科臨床リュミエール26) (2011)
  • Author(s): 福居顯二
  • Total Pages: 244
  • Publisher: 中山書店
• [Book] 依存症・衝動制御障害の治療 (2011)
  • Author(s): 福居顯二
  • Total Pages: 234
  • Publisher: 中山書店