| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
The aim of this study is to clarify a prodromal state of dementia with Lewy bodies (DLB) and to lead to an early diagnosis and therapy of DLB. From the results of this study, it has been indicated that the patients showing progression to DLB have prodromal symptoms such as RRM sleep behavior disorder, autonomic symptoms, olfactory dysfunction and depression before the onset of cognitive impairment, and that glucose hypometabolism in primary visual cortex on brain FDG-PET and decrease MIBG uptake on MIBG cardiac scintigraphy are already observed in non-demented or mild cognitive impaiment patients with these prodromal symptoms. When patients with prodromal symptoms exhibit characteristic findings on these functional imagings, a preventive therapy should be given for the patients as a prodromal DLB.
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