Clinicopathological study on early diagnosis of dementia with Lewy bodies
| Project/Area Number |
23591729
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Juntendo University |
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Principal Investigator |
ISEKI Eizo 順天堂大学, 医学部, 教授 (30203061)
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| Co-Investigator(Kenkyū-buntansha) |
FUJISHIRO Hiroki 順天堂大学, 医学部, その他 (20536924)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | レビー小体型認知症 / 免疫組織化学 / オートファジー・ライソゾーム系 / 123I-MIBG心筋シンチグラフィー / 18F-FDG PET / α-シヌクレイン病理 / タウ病理 / Aβ病理 / 頭部FDG-PET検査 / MIBG心筋シンチグラフィー検査 / 前駆状態 / 心筋MIBG心筋シンチグラフィー検査 |
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| Research Abstract |
The aim of this study is to clarify a prodromal state of dementia with Lewy bodies (DLB) and to lead to an early diagnosis and therapy of DLB. From the results of this study, it has been indicated that the patients showing progression to DLB have prodromal symptoms such as RRM sleep behavior disorder, autonomic symptoms, olfactory dysfunction and depression before the onset of cognitive impairment, and that glucose hypometabolism in primary visual cortex on brain FDG-PET and decrease MIBG uptake on MIBG cardiac scintigraphy are already observed in non-demented or mild cognitive impaiment patients with these prodromal symptoms. When patients with prodromal symptoms exhibit characteristic findings on these functional imagings, a preventive therapy should be given for the patients as a prodromal DLB.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients with dementia with Lewy bodies2012
Author(s)
Kasanuki K, Iseki E, Fujishiro H, Yamamoto R, Higashi S, Minegishi M, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H
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Journal Title
J Neurol Sci.
Volume: 314(1-2)
Issue: 1-2
Pages: 111-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies.2011
Author(s)
Higashi S, Moore DJ, Minegishi M, Kasanuki K, Fujishiro H, Kabuta T, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H, Wada K, Iseki E
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Journal Title
J Neuropathol Exp Neurol
Volume: 70(4)
Issue: 4
Pages: 264-80
DOI
Related Report
Peer Reviewed
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