| Project/Area Number |
23591808
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | 秋田県立脳血管研究センター(研究部門) |
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Principal Investigator |
KINOSHITA Toshibumi 秋田県立脳血管研究センター(研究局), その他部局等, 研究員 (70314599)
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| Co-Investigator(Kenkyū-buntansha) |
IBARAKI Masanobu 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 主任研究員 (40360359)
KINOSHITA Fumiko 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 主任研究員 (50304225)
UMETSU Atsushi 秋田県立脳血管研究センター(研究部門), 放射線医学研究部, 主任研究員 (40370259)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | CT / MRI / 灌流画像 / 脳梗塞 / 二次変性 / 遠隔効果 / 拡散テンソル |
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| Outline of Final Research Achievements |
Crossed cerebellar diaschisis (CCD) is characterized by a reduction in blood flow in the cerebellar hemisphere contralateral to a supratentorial infarction. CT perfusion study was performed using a 320-detector row CT. In patients with acute cerebral infarction in the unilateral middle cerebral artery territory, CCD was positive at CBF and CBV maps. Circulation delay was observed in the affected cerebral hemisphere at 4D-CTA. Our results suggest that CT perfusion using 320-detector row CT is helpful in identifying CCD.
In the subacute period of striatal infarction, MR imaging revealed secondary degeneration of the ipsilateral substantia nigra with abnormal T2 signal and restricted water diffusion. In the late subacute period of middle cerebral artery infarction, diffusion-weighted imaging disclosed involvement of the ipsilateral dorsomedial thalamus with restricted water diffusion.
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