Relationship between cerebral perfusion/neuronal activity and amyloid deposition

• Project/Area Number: 23591809
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: SEKI Chie 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (40443080)
• Co-Investigator(Renkei-kenkyūsha): HIGUCHI Makoto 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10373359)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 放射線 / 脳神経疾患 / 痴呆 / 老化

Research Abstract

It has been considered that decreased cerebral blood flow may accelerate Alzheimer's disease (AD) related pathologies. To investigate the impact of lowered regional cerebral blood flow (rCBF) on the formation of amyloid beta (Abeta) deposition, unilateral cerebral hypoperfusion model was made on amyloid precursor protein transgenic (APP Tg) mice by the ligation of the left common carotid artery. The progression of Abeta depositions and rCBF were quantitatively monitored with [11C]PIB-PET and MRI over months. The rCBF of ipsilaterel neocortex sustained up to 84% of that of contralateral neocortex. The Abeta deposition increased and expanded over time without laterality related to hypoperfusion. The current results indicate that chronic cerebral hypoperfusion is not considered to accelerate deposition of Abeta plaques.
In vivo imaging technologies such as PET and MRI have advantageous to visualize alterations of Abeta depositions and rCBF in living model mouse brains longitudinally.

Research Products

• [Presentation] アルツハイマー病モデルマウス脳切片を用いた[11C]PIBの異なるアミロイドβ蓄積病理への結合評価 (2013)
  • Author(s): 関千江, 小野麻衣子, 季斌, 徳永正希, 丸山将浩, 須原哲也, 樋口真人, 伊藤浩
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡国際会議場, 福岡市
• [Presentation] Chronic cerebral hypoperfusion did not accelerate [11C]PIB-reactive Abeta deposition in amyloid precursor protein transgenic mice (2013)
  • Author(s): Seki C, Higuchi M, Tokunaga M, Maruyama M, Ono M, Jin B, Maeda J, Nitta N, Aoki I, Suhara T, Ito H
  • Organizer: XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function
  • Place of Presentation: Shanghai, China
• [Presentation] Chronic cerebral hypoperfusion did not accelerate [11C]PIB-reactive Abeta deposition in amyloid precursor protein transgenic mice. (2013)
  • Author(s): Seki C, Higuchi M, Tokunaga M, Maruyama M, Ono M, Jin B, Maeda J, Nitta N, Aoki I, Suhara T, Ito H
  • Organizer: XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function.
  • Place of Presentation: Shanghai International Convention Center, Shanghai, China
• [Presentation] アルツハイマー病モデルマウス脳切片を用いた[11C]PIBの異なるアミロイドβ蓄積病理への結合評価 (2013)
  • Author(s): 関 千江, 小野 麻衣子, 季 斌, 徳永 正希, 丸山 将浩, 須原 哲也, 樋口 真人, 伊藤 浩
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡国際会議場、福岡市
• [Presentation] Chronic cerebral hypoperfusion did not accelerate [11C]PIB-reactive Aβ deposition in amyloid precursor protein transgenic mice. (2013)
  • Author(s): Chie Seki, Makoto Higuchi, Masaki Tokunaga, Masahiro Murayama, Maiko Ono, Bin Ji,
  • Organizer: 11th International Conference on Quantification of Brain Function with PET
  • Place of Presentation: Shanghai International Convention Center Shanghai, China.
• [Presentation] アミロイド前駆体蛋白遺伝子導入マウスでのアミロイドβ蓄積と[^<11>C]PIBの動態パラメータの関係 (2012)
  • Author(s): 関千江, 徳永正希, 丸山将浩, 小野麻衣子, 季斌, 前田純, 須原哲也, 樋口真人, 伊藤浩
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌, 札幌市
• [Presentation] Relationship between kinetic parameters of [11C]PIB and amyloidβdeposition studied in amyloid precursor protein transgenic mouse brains (2012)
  • Author(s): Seki C, Tokunaga M, Hattori S, Murayama M, Ono M, Ji B, Maeda J, Suhara T, Higuchi M, Ito H
  • Organizer: Neuroreceptor Mapping Congress
  • Place of Presentation: Johns Hopkins University, Baltimore, Maryland, U.S.A
• [Presentation] Evaluation of regional cerebral blood flow using [^<11>C]PIB in unilateral cerebral hypoperfusion model mice (2011)
  • Author(s): Seki C, Higuchi M, Saito S, Tokunaga M, Maruyama M, Okauchi T, Aoki I, Ito H, and Suhara T
  • Organizer: Annual Meeting of Society for Neuroscience 2011
  • Place of Presentation: Washington Covention Center, Washington, D.C., USA
• [Presentation] [11C]PIBによる片側脳低灌流モデルマウスの局所脳血流量評価 (2011)
  • Author(s): 関千江, 樋口真人, 齋藤茂芳, 徳永正希, 丸山将浩, 岡内隆, 青木伊知男, 伊藤浩, 須原哲也
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場, つくば市
• [Presentation] Evaluation of regional cerebral blood flow using [11C]PIB in unilateral cerebral hypoperfusion model mice. (2011)
  • Author(s): Seki C, Higuchi M, Saito S, Tokunaga M, Maruyama M, Okauchi T, Aoki I, Ito H, and Suhara T
  • Organizer: Annual Meeting of Society for Neuroscience 2011
  • Place of Presentation: Washington Covention Center, Washington, D.C., USA.
• [Presentation] 「[11C]PIBによる片側脳低灌流モデルマウスの局所脳血流量評価」 (2011)
  • Author(s): 関 千江、 樋口 真人、 齋藤 茂芳、 徳永 正希、 丸山 将浩、 岡内 隆、 青木 伊知男、 伊藤 浩、 須原 哲也
  • Organizer: 第５１回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場、つくば市