Development of a dose conversion model applicable to single and hypofractionated irradiation
| Project/Area Number |
23591846
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagoya City University |
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Principal Investigator |
SHIBAMOTO Yuta 名古屋市立大学, 医学(系)研究科(研究院), 教授 (20144719)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIE Chikao 名古屋市立大学, 大学院・医学研究科, 准教授 (80509258)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | LQモデル / BED / 再酸素化 / Linear-quadratic model / Reoxygenation / 線量換算式 / EMT6細胞 / α/β比 / 寡分割照射 |
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| Outline of Final Research Achievements |
This study aimed to develop a dose conversion model that is applicable to single and hypofractionated irradiation. Using the linear-quadratic model, EMT6 cells were irradiated to the same biological effective dose (BED) with various fractionation schedules. Despite the same BED, the effects of 1 to 5 fractions of irradiation were significantly lower than those of 7 or more fraction irradiation. Thus, the LQ model was considered only applicable to 7 or more fraction irradiation. It was concluded that the BED overestimates the biological effects of hypofractionated doses. An ideal model to convert the dose was difficult. However, by discounting 15-20% of the BED calculated using the LQ model, it was considered that actual biological effects could be roughly predicted.
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Long-Term Outcome of Proton Therapy and Carbon-Ion Therapy for Large (T2a-T2bN0M0) Non-Small-Cell Lung Cancer2013
Author(s)
Iwata H, Demizu Y, Fujii O, Terashima K, Mima M, Niwa Y, Hashimoto N, Akagi T, Sasaki R,Hishikawa Y, Abe M, Shibamoto Y, Murakami M, Fuwa N
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Journal Title
J Thorac Oncol
Volume: Epub ahead of print
Issue: 6
Pages: 726-35
DOI
Related Report
Peer Reviewed
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