| Project/Area Number |
23591859
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYATA Tetsurou 東京大学, 医学部附属病院, 届出研究医 (70190791)
SHIGEMATSU Kunihiro 東京大学, 医学部附属病院, 講師 (20215966)
OKAMOTO Hiroyuki 東京大学, 医学部附属病院, 特任教師 (60348266)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血管外科学 / drug delivery system / ナノミセル / 腹部大動脈瘤 / ドラッグデリバリー / Drug Delivery System / PICsome / ドラッグデリバリーシステム / ナノ粒子 |
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| Research Abstract |
We investigated the effect of nanomicelle on a rat aneurysm model for the purpose of exploiting a novel drug delivery system for the abdominal aortic aneurysm. We injected polyion complex hallow vesicle (PICsome), which is a fluorescent-labeled and size-changeable nano particle, into a rat aneurysm model. We revealed that the nano particle gathered and retained in an abdominal aortic aneurysmal wall, the degree of the aggregation was dependent on the particle size, and the particle gathered on the medial layer retained relatively for a long term. From these data, we assumed that PICsome should be a promising material for the drug delivery system for the abdominal aortic aneurysm.
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