| Project/Area Number |
23591869
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOMATA Yukihiro 熊本大学, 大学院生命科学研究部, 教授 (50193628)
SHIRAISHI Shinya 熊本大学, 大学院生命科学研究部, 助教 (50433008)
YOSHIDA Morikatsu 熊本大学, 医学部附属病院, 助教 (20508494)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 生体肝移植 / 生体ドナー / 肝予備能解析 |
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| Research Abstract |
The purpose of this study is to evaluate hepatic function of living donor by use of 99m Tc-Galactosyl serum albumin (GSA) single-photon emission computed tomography (SPECT)/CT 3D fused imaging.
A total of 65 living donors who underwent hepatectomy were enrolled. The liver uptake ratio (LUR) were calculated based on fused imaging preoperatively and postoperatively. LUR was lower in the cases with pathological liver steatosis and fibrosis. LUR wasn't related to aged liver. The changing ratio in remnant liver volumes between one and four weeks were 0.89-2.11 (median; 1.33) and 0.96-2.73 (median; 1.48). The changes of LUR value of remnant liver between one and four weeks after LDLT were 0.92-1.77 (median; 1.32) and 0.83-1.44 (median; 1.02), respectively. Postoperative hyperbillirubinemia were associated with lower remnant liver volume and preoperative LUR. In conclusion, 99mTc-GSA SPECT/CT fused imaging was clinically useful to evaluate postoperative hepatic function of living donor.
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