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Effectiveness for islet isolation by hypothermic machine perfusion presevation of pancreas

Research Project

Project/Area Number 23591887
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionClinical research Center, Chiba-East National Hospital, National Hospital Organization

Principal Investigator

AKUTSU Naotake  独立行政法人国立病院機構(千葉東病院臨床研究センター), その他部局等, その他 (00344979)

Co-Investigator(Kenkyū-buntansha) OTSUKI Kazunori  国立病院機構千葉東病院, 臨床研究部, 室長 (50399755)
MARUYAMA Michihiro  国立病院機構千葉東病院, 診療部長 (40399754)
KENMOCHI Takashi  藤田保健衛生大学, 医学部臓器移植科, 教授 (50215133)
ITO Taihei  藤田保健衛生大学, 医学部臓器移植科, 准教授 (60509701)
Co-Investigator(Renkei-kenkyūsha) SAIGO Kenichi  国立病院機構千葉東病院, 診療部長 (60323424)
HASEGAWA Masayuki  国立病院機構千葉東病院, 外科医長 (80648030)
AOYAMA Hiromichi  国立病院機構千葉東病院, 外科医師 (80598243)
MATSUMOTO Ikuko  国立病院機構千葉東病院, 外科医師 (70649128)
NOGUCHI Hirofumi  琉球大学, 医学部再生医学講座, 教授 (50378733)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵島移植 / 臓器保存 / 持続冷却潅流保存 / 膵臓保存 / 移植・再生医療 / 移植 / 膵ランゲルハンス島(膵島) / 灌流保存
Outline of Final Research Achievements

Hypothermic machine perfusion preservation (HMP) by LifePortTM is thought to be a better preservation technique for pancreas harvested from marginal donors such as non-heart-beating donor. In this experiment, we indicated that yield and function of islet isolated from 24hours-preserved canine pancreas with LifePortTM removed after 30 minutes warm ischemic time. It suggests that HMP for pancreas would be a useful method for islet transplantation from marginal donors in Japan.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2015 2014 2012 2011

All Journal Article (1 results) Presentation (3 results)

  • [Journal Article] 持続灌流装置(LifePort)による障害腎・膵の保存・搬送に関する実験的研究2011

    • Author(s)
      圷 尚武 他
    • Journal Title

      Organ Biology

      Volume: 18 Pages: 81-86

    • NAID

      130004709987

    • Related Report
      2011 Research-status Report
  • [Presentation] 心停止下膵島移植に向けたLifePortによる持続冷却潅流保存の検討2015

    • Author(s)
      圷尚武
    • Organizer
      第42回日本膵・膵島移植研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-06 – 2015-03-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 膵島移植に向けた採取膵持続潅流保存の検討2014

    • Author(s)
      圷尚武
    • Organizer
      第41回日本臓器保存生物医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-28 – 2014-11-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Hypotheramic machine perfusion preservation is efficient for non-heart-beating donor kidney transplantation in Japan2012

    • Author(s)
      Akutsu N, Kenmochi T, Saitoh T, Maruyama M, Iwashita C, Otsuki K, Ito T, Matsumoto I, Asano T
    • Organizer
      24th International Congress of the Transplantation Society
    • Place of Presentation
      Berlin
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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