| Project/Area Number |
23591887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Clinical research Center, Chiba-East National Hospital, National Hospital Organization |
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Principal Investigator |
AKUTSU Naotake 独立行政法人国立病院機構(千葉東病院臨床研究センター), その他部局等, その他 (00344979)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKI Kazunori 国立病院機構千葉東病院, 臨床研究部, 室長 (50399755)
MARUYAMA Michihiro 国立病院機構千葉東病院, 診療部長 (40399754)
KENMOCHI Takashi 藤田保健衛生大学, 医学部臓器移植科, 教授 (50215133)
ITO Taihei 藤田保健衛生大学, 医学部臓器移植科, 准教授 (60509701)
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| Co-Investigator(Renkei-kenkyūsha) |
SAIGO Kenichi 国立病院機構千葉東病院, 診療部長 (60323424)
HASEGAWA Masayuki 国立病院機構千葉東病院, 外科医長 (80648030)
AOYAMA Hiromichi 国立病院機構千葉東病院, 外科医師 (80598243)
MATSUMOTO Ikuko 国立病院機構千葉東病院, 外科医師 (70649128)
NOGUCHI Hirofumi 琉球大学, 医学部再生医学講座, 教授 (50378733)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵島移植 / 臓器保存 / 持続冷却潅流保存 / 膵臓保存 / 移植・再生医療 / 移植 / 膵ランゲルハンス島（膵島） / 灌流保存 |
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| Outline of Final Research Achievements |
Hypothermic machine perfusion preservation (HMP) by LifePortTM is thought to be a better preservation technique for pancreas harvested from marginal donors such as non-heart-beating donor. In this experiment, we indicated that yield and function of islet isolated from 24hours-preserved canine pancreas with LifePortTM removed after 30 minutes warm ischemic time. It suggests that HMP for pancreas would be a useful method for islet transplantation from marginal donors in Japan.
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