| Project/Area Number |
23591910
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Fujita Health University |
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Principal Investigator |
HIBI Ystsuka 藤田保健衛生大学, 医学部, 准教授 (10399024)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUNO Yutaka 藤田保健衛生大学, 医学部, 講師 (90595977)
IMAI Tsuneo 名古屋大学, 医学部附属病院, 講師 (80252245)
KIKUMORI Toyone 名古屋大学, 医学部附属病院, 講師 (90402635)
IWASE Katsumi 藤田保健衛生大学, 医学部, 教授 (70148261)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 原発性副甲状腺機能亢進症 / PRKAR1α / PKA / 副甲状腺機能亢進症 / ｃAMP/PKAシグナリング / 上皮小体 / 線腫 / 上皮小体機能亢進症 |
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| Research Abstract |
protein kinase A (PKA) regulatory subunit type 1a (R1a) is a major regulatory subunit that functions as an inhibitor of PKA kinase activity. Surgical specimens comprising 22 adenomas and 11 normal glands, obtained from 22 patients with primary hyperparathyroidism (PHPT), were analyzed. Western blot analysis revealed that 5 out oh 8 adenomas high expressed of R1a, compared with normal glands. PKA activity in adenoma was significantly less in normal glands. Immunohistochemical analysis further demonstrated high expression of R1a in 20 out of 22 adenomas. The study suggested that R1a expression could contribute to monoclonal proliferation of parathyroid cells by impairing the cAMP/PKA signaling pathway.
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