The role of proton-sensing G-protein coupled receptors(GPCRs) in the regulation of inflammatory cytokine production during endoscopic surgery
| Project/Area Number |
23591916
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Gunma Institute of Public Health and Environmental Sciences |
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Principal Investigator |
MURATA Naoya 群馬県衛生環境研究所, 研究企画係, 研究員 (00533473)
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| Co-Investigator(Kenkyū-buntansha) |
OKAJIMA Fumikazu 群馬大学, 生体調節研究所, 教授 (30142748)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | プロトン感知性受容体 / OGR1受容体ファミリー / TDAG8 / 抗炎症性応答 / 実験外科学 |
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| Research Abstract |
The role of proton-sensing GPCRs in the regulation of lipopolysaccharide(LPS)-induced inflammatory cytokine production was investigated. In vivo injection of LPS into mice resulted in the remarkable accumulation of TNF-alpha. The LPS-induced action tends to be enhanced in the mice deficient in TDAG8 or GPR4; however, the effects of receptor deficiency were not significant. Extracellular acidification inhibited LPS-induced TNF-alpha protein and mRNA production in mouse peritoneal macrophages in vitro. Our results suggest that acidic pH inhibits inflammatory cytokine production at least partly through TDAG8/cAMP/PKA pathways in mouse macrophages.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model2013
Author(s)
Aoki H, Mogi C, Hisada T, Kamide Y, Ichimonji I, Tomura H, Tobo M, Sato K, Tsurumaki H, Dobashi K, Mori T, Harada H, Yamada M, Mori M, Ishizuka T, Okajima F
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Journal Title
PLoS ONE
Volume: 8(11)
Issue: 11
Pages: e79985-e79985
DOI
Related Report
Peer Reviewed
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