| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
From mouse embryonic stem (ES) cells, the gut-like organ expressing peristalsis-like movements could be stably formed. In this gut, pacemaker cells (ICC) generating peristalsis-like movements could be stably differentiated without any differentiation inducing factors.
In the present study, during the process forming the ES gut, a special neuron differentiation inducing factor (serotonin 4 receptor agonist) was applied, succeeding in formation of ES guts expressing more perfect peristalses.
The results of this study would provide many hints to clarify the conditions and explore therapies of bowel diseases lacking enteric neurons.
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