Elucidation of the proliferative mechanism of liver cancer stem cell based on the study of embryonal stem cell

• Project/Area Number: 23591982
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kanazawa University
• Principal Investigator: TAKAMURA HIROYUKI 金沢大学, 大学病院, 助教 (40377396)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: Zfp57 / がん幹細胞 / Nanog

Research Abstract

Zfp57 is required for the tumorigenicity and hematogenous metastaic ability of humoral cancer cell line by upregulating IGF2 expression and Zfp57 activates AKT through IGF2 signaling.
Zfp57 is over-expressed in several humoral cancer tissues and especially in liver metastasis of colorectal cancer.

Research Products

• [Journal Article] The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells. (2014)
  • Author(s): Tada Y, Yamaguchi Y, Kinjo T, Song X, Akagi T, Takamura H, Ohta T, Yokota T, Koide H.
  • Journal Title: Oncogene Volume: Jan 27 Issue: 6 Pages: 1-9
  • DOI: 10.1038/onc.2013.599
  • NAID: 120005428400
  • Peer Reviewed
• [Presentation] ES細胞特異的遺伝子Zfp57は癌遺伝子として機能する (2014)
  • Author(s): 高村博之,山口紫,庄司泰弘,他
  • Organizer: 第114回日本外科学会総会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2014-04-05
• [Presentation] ES細胞特異的遺伝子Zfp57は癌遺伝子として機能する (2014)
  • Author(s): 高村博之，山口 紫，庄司泰弘，田夛祐喜，赤木紀之，小出 寛，正司 政寿，中沼伸一，林 泰寛，渡辺 利史，岡本浩一，酒井清祥，牧野 勇，木下 淳，中村慶史，尾山勝信，中川原寿俊，宮下知治，田島秀浩，二宮 致，北川裕久，伏田幸夫，藤村 隆，横田 崇，太田哲生
  • Organizer: 第114回 日本外科学会総会
  • Place of Presentation: 京都国際会議場