|Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Senescence is the irreversible cell cycle arrest for the shortage of telomea. We identified gene HJURP (Holliday junction recognition protein) as Oncogene induced Senescence connection gene. HJURP is one kind of the histone chaperon. HJURP is highly expressed in human cholangiocarcinoma cell strain and pancreatic cancer cell strain. HJURP siRNA suppressed the cell proliferation in cholangiocarcinoma cell strain. In addition, we examined the combination treatment of anticancer agent CDDP and HJURP siRNA. The cell proliferation was inhibited in HJURP siRNA2 group, compared to control siRNA group. HJURP siRNA2 enhanced the effect of anticancer agent CDDP.
Next, the prognosis is poor in the overexpression group of HJURP in cholangiocarcinoma and pancreatic cancer. Our data suggested that HJURP may be a prognostic prediction marker in the pancreatic cancer and cholangiocarcinoma.