Identification of mechanism of hepatocarcinogenesis by analysi of microRNA
| Project/Area Number |
23591994
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
KUBO Shoji 大阪市立大学, 医学(系)研究科(研究院), 准教授 (80221224)
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| Co-Investigator(Kenkyū-buntansha) |
TAMORI Akihiro 大阪市立大学, 大学院医学研究科, 准教授 (30291595)
MURAKAMI Yoshiki 大阪市立大学, 大学院医学研究科, 准教授 (00397556)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肝細胞癌 / がん遺伝子 / マイクロRNA / 生活習慣病 |
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| Research Abstract |
The mechanism of hepatocarcinogenesis was investigated using microRNA obtained from patients with hepatocellular carcinoma. The expression of 12 miRNA, especially miR-18b expression, varied significantly correlated to degree of histological differentiation. miR-18b can control the expression of trinucleotide repeat containing 6B as a target gene. Over-expression of miR-18b or down-regulation of TNCR6B accelerated cell proliferation and loss of cell adhesion ability. HCC patients with high miR-18b expression had a significantly shorter relapse-free period than those with low expression. miR-18b is a diagnostic and prognostic marker for HCC progression.
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Report
(4 results)
Research Products
(88 results)
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[Journal Article] Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan.2014
Author(s)
Kubo S, Nakanuma Y, Takemura S, Sakata C, Urata Y, Nozawa A, Nishioka T, Kinoshita M, Hamano G, Terajima H, Tachiyama G, Matsumura Y, Yamada T, Tanaka H, Nakamori S, Arimoto A, Kawada N, Fujikawa M, Fujishima H, Sugawara Y, Tanaka S, Toyokawa H, Kuwae Y, Ohsawa M, Uehara S, Sato KK, Hayashi T, Endo G.
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Journal Title
J Hepatobiliary Pancreat Sci.
Volume: 21
Issue: 7
Pages: 479-488
DOI
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Peer Reviewed / Open Access
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[Journal Article] The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis2013
Author(s)
Murakami Y, Tamori A, Itami S, Tanahashi T, Toyoda H, Tanaka M, Wu W, Brojigin N, Kaneoka Y, Maeda A, Kumada T, Kawada N, Kubo S and Kuroda M.
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Journal Title
BMC Cancer
Volume: 13
Issue: 1
Pages: 99-99
DOI
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Peer Reviewed
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[Journal Article] Effects of antiviral therapy on the long-term outcome after liver resection for hepatitis B virus-related hepatocellular carcinoma2012
Author(s)
Urata Y, Kubo S, Takemura S, Uenishi T, Kodai S, Shinkawa H, Sakae M, Kaneda K, Ohata K, Nozawa A, Suehiro S
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Journal Title
Journal of Hepato-Biliary-Pancreatic Sciences
Volume: 19
Issue: 6
Pages: 685-696
DOI
NAID
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Peer Reviewed
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[Journal Article] Effect of interferon therapy on first and second recurrence after resection of hepatitis C virus-related hepatocellular carcinoma2012
Author(s)
Sakae M, Kubo S, Takemura S, Sakata C, Uenishi T, Kodai S, Shinkawa H, Urata Y, Ohata K, Kaneda K, Nishioka T, Nozawa A, Suehiro S
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Journal Title
Hepatology Research
Volume: VOL.18
Issue: 6
Pages: 564-573
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery2011
Author(s)
Uchiyama K, Yamamoto M, Yamaue H, Ariizumi S, Aoki T, Kokudo N, Ebata T, Nagino M, Ohtsuka M, Miyazaki M, Tanaka E, Kondo S, Uenishi T, Kubo S, Yoshida H, Unno M, Imura S, Shimada M,
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Journal Title
Journal of Hepato-Biliary-Pancreatic Sciences
Volume: VOL.18
Issue: 3
Pages: 443-452
DOI
NAID
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Peer Reviewed
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[Presentation] Features of recurrence-free survival for more than 10 years after liver resection for hepatocellular carcinoma2011
Author(s)
Ohata K, Uenishi T, Takemura S,Kiyota S, Shinkawa H, Urata Y, Kaneda K, Sakae M, Nozawa A, Kubo S
Organizer
21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2011)
Place of Presentation
京王プラザホテル（東京都）
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[Book] 肝細胞癌2011
Author(s)
久保正二、竹村茂一
Total Pages
6
Publisher
総合医学社
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