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Identification of mechanism of hepatocarcinogenesis by analysi of microRNA

Research Project

Project/Area Number 23591994
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionOsaka City University

Principal Investigator

KUBO Shoji  大阪市立大学, 医学(系)研究科(研究院), 准教授 (80221224)

Co-Investigator(Kenkyū-buntansha) TAMORI Akihiro  大阪市立大学, 大学院医学研究科, 准教授 (30291595)
MURAKAMI Yoshiki  大阪市立大学, 大学院医学研究科, 准教授 (00397556)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肝細胞癌 / がん遺伝子 / マイクロRNA / 生活習慣病
Research Abstract

The mechanism of hepatocarcinogenesis was investigated using microRNA obtained from patients with hepatocellular carcinoma. The expression of 12 miRNA, especially miR-18b expression, varied significantly correlated to degree of histological differentiation. miR-18b can control the expression of trinucleotide repeat containing 6B as a target gene. Over-expression of miR-18b or down-regulation of TNCR6B accelerated cell proliferation and loss of cell adhesion ability. HCC patients with high miR-18b expression had a significantly shorter relapse-free period than those with low expression. miR-18b is a diagnostic and prognostic marker for HCC progression.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (88 results)

All 2014 2013 2012 2011 Other

All Journal Article (28 results) (of which Peer Reviewed: 21 results,  Open Access: 1 results) Presentation (53 results) (of which Invited: 1 results) Book (7 results)

  • [Journal Article] Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan.2014

    • Author(s)
      Kubo S, Nakanuma Y, Takemura S, Sakata C, Urata Y, Nozawa A, Nishioka T, Kinoshita M, Hamano G, Terajima H, Tachiyama G, Matsumura Y, Yamada T, Tanaka H, Nakamori S, Arimoto A, Kawada N, Fujikawa M, Fujishima H, Sugawara Y, Tanaka S, Toyokawa H, Kuwae Y, Ohsawa M, Uehara S, Sato KK, Hayashi T, Endo G.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 21 Issue: 7 Pages: 479-488

    • DOI

      10.1002/jhbp.86

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 最新の肝切離法2013

    • Author(s)
      久保正二、他
    • Journal Title

      外科

      Volume: 75 Pages: 1158-1164

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Impact of laparoscopic liver resection for hepatocelular carcinoma with F4-liver cirrhosis2013

    • Author(s)
      Kanazawa A, Kubo S, et al.
    • Journal Title

      Surgical Endoscopy

      Volume: 27 Pages: 2592-2597

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a miR-26 companion diagnostic test for adjuvant interferon-alpha therapy in hepatocellular carcinoma2013

    • Author(s)
      Murakami Y, Tamori S, Kubo S, et al.
    • Journal Title

      International Journal of Biolological Sciences

      Volume: 9 Pages: 303-312

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological features of recurrence in patients after 10-year disease-free survival following curative hepatic resection of hepatocellular carcinoma2013

    • Author(s)
      Kaibori M, Kubo S, et al.
    • Journal Title

      World Journal of Surgery

      Volume: 37 Pages: 820-828

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis2013

    • Author(s)
      Murakami Y, Tamori A, Itami S, Tanahashi T, Toyoda H, Tanaka M, Wu W, Brojigin N, Kaneoka Y, Maeda A, Kumada T, Kawada N, Kubo S and Kuroda M.
    • Journal Title

      BMC Cancer

      Volume: 13 Issue: 1 Pages: 99-99

    • DOI

      10.1186/1471-2407-13-99

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝細胞癌破裂2012

    • Author(s)
      久保正二、他
    • Journal Title

      外科

      Volume: 74 Pages: 382-387

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 肝癌治療ガイドラインについて2012

    • Author(s)
      久保正二、他
    • Journal Title

      外科

      Volume: 74 Pages: 191-198

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
  • [Journal Article] Effects of antiviral therapy on the long-term outcome after liver resection for hepatitis B virus-related hepatocellular2012

    • Author(s)
      Urata Y, Kubo S, et al.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 19 Pages: 685-696

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of microwave tissue coagulation on postoperative complications in patients who underwent liver resection2012

    • Author(s)
      Kubo S, et al.
    • Journal Title

      Journal of Microwave Surgery

      Volume: 30 Pages: 159-162

    • NAID

      130004678979

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The influence of postoperative glycemic control on recurrence after curative resection in diabetics with hepatitis C virus-related hepatocellular carcinoma2012

    • Author(s)
      Kaneda K, Kubo S, et al.
    • Journal Title

      Journal of Surgical Oncology

      Volume: 105 Pages: 606-611

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Features and outcome after liver resection for non-B non-C hepatocellular carcinoma2012

    • Author(s)
      Kaneda K, Kubo S, et al.
    • Journal Title

      Hepatogastroenterology

      Volume: 59 Pages: 1889-1892

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of interferon therapy on first and second recurrence after resection of hepatitis C virus-related hepatocellular carcinoma2012

    • Author(s)
      Sakae M, Kubo S, et al.
    • Journal Title

      Hepatology Research

      Volume: 42 Pages: 564-573

    • NAID

      10031144271

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The influence of postoperative glycemic control on recurrence after curative resection in diabetics with hepatitis C virus-related hepatocellular carcinoma.2012

    • Author(s)
      Kaneda K, Uenishi T, Takemura S, Shinkawa H, Urata Y, Sakae M, Yamamoto T, Kubo S
    • Journal Title

      Journal of Surgical Oncology

      Volume: 105 Pages: 606-611

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of antiviral therapy on the long-term outcome after liver resection for hepatitis B virus-related hepatocellular carcinoma2012

    • Author(s)
      Urata Y, Kubo S, Takemura S, Uenishi T, Kodai S, Shinkawa H, Sakae M, Kaneda K, Ohata K, Nozawa A, Suehiro S
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 19 Issue: 6 Pages: 685-696

    • DOI

      10.1007/s00534-011-0489-z

    • NAID

      10031126985

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肝切除術における予防的抗菌薬投与と手術部位感染の実態2012

    • Author(s)
      久保正二、竹村茂一、上西崇弘、坂田親治、浦田順久、大畑和則、金田和久、西岡孝芳、野沢彰紀、松田常美、新川寛二、清田誠志
    • Journal Title

      日本外科感染症学会雑誌

      Volume: 9 Pages: 1-7

    • NAID

      40019387414

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肝切除手術手技の実態に関する多施設アンケート調査報告ー大阪府下5大学およびその関連28施設の現状ー2012

    • Author(s)
      海堀昌樹、永野浩昭、土師誠二、林 道廣、久保正二、權 雅憲
    • Journal Title

      臨床外科

      Volume: 74 Pages: 1521-1528

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ウィルス性肝炎と肝内胆管癌2012

    • Author(s)
      上西崇弘、山本隆嗣、竹村茂一、坂田親治、久保正二
    • Journal Title

      日本消化器病学会雑誌

      Volume: 109 Pages: 1872-1877

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 糖尿病コントロール後に自然退縮した肝細胞癌の1症例2012

    • Author(s)
      山本訓史、徳原太豪、西川正博、西澤 聡、西岡孝芳、野沢彰紀、高橋 亮、渡邊芳久、和田力門、若狭研一、久保正二
    • Journal Title

      肝臓

      Volume: 53巻

    • NAID

      10030547310

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Influence of Postoperative Glycemic Control on Recurrence After Curative Resection in Diabetics With Hepatitis C Virus-Related Hepatocellular Carcinoma2012

    • Author(s)
      Kaneda K, Uenishi T, Takemura S, Shinkawa H, Urata Y, Sakae M, Yamamoto T, Kubo S
    • Journal Title

      Journal of Surgical Oncology

      Volume: VOL.105 Issue: 6 Pages: 606-611

    • DOI

      10.1002/jso.22137

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of interferon therapy on first and second recurrence after resection of hepatitis C virus-related hepatocellular carcinoma2012

    • Author(s)
      Sakae M, Kubo S, Takemura S, Sakata C, Uenishi T, Kodai S, Shinkawa H, Urata Y, Ohata K, Kaneda K, Nishioka T, Nozawa A, Suehiro S
    • Journal Title

      Hepatology Research

      Volume: VOL.18 Issue: 6 Pages: 564-573

    • DOI

      10.1111/j.1872-034x.2011.00959.x

    • NAID

      10031144271

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] サイトケラチン19陽性肝細胞癌の臨床学的特徴2011

    • Author(s)
      上西崇弘、久保正二、他
    • Journal Title

      肝胆膵

      Volume: 63 Pages: 671-675

    • Related Report
      2013 Final Research Report
  • [Journal Article] 肝細胞癌に対する肝切除術の周術期管理2011

    • Author(s)
      竹村茂一、久保正二、他
    • Journal Title

      消化器外科

      Volume: 34 Pages: 1099-1107

    • Related Report
      2013 Final Research Report
  • [Journal Article] 肝切除術におけるドレーン管理-肝切除術において腹腔ドレーンは必要か?-2011

    • Author(s)
      久保正二、他
    • Journal Title

      日本門脈圧亢進症学会雑誌

      Volume: 17 Pages: 52-55

    • NAID

      130003388339

    • Related Report
      2013 Final Research Report
  • [Journal Article] 肝細胞癌治療における背景肝病変の意義2011

    • Author(s)
      西口修平、川口 巧、久保正二、田中弘教、能祖一裕
    • Journal Title

      The LIVER CANCER JOURNAL

      Volume: 3巻

    • Related Report
      2011 Research-status Report
  • [Journal Article] Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery2011

    • Author(s)
      Uchiyama K, Yamamoto M, Yamaue H, Ariizumi S, Aoki T, Kokudo N, Ebata T, Nagino M, Ohtsuka M, Miyazaki M, Tanaka E, Kondo S, Uenishi T, Kubo S, Yoshida H, Unno M, Imura S, Shimada M,
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: VOL.18 Issue: 3 Pages: 443-452

    • DOI

      10.1007/s00534-010-0349-2

    • NAID

      10029287252

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The long-term outcomes after curative resection for mass-forming intrahepatic cholangiocarcinoma associated with hepatitis C viral infection : A multicenter analysis by Osaka Hepatic Surgery Study Group

    • Author(s)
      Uenishi T, Kubo S, et al.
    • Journal Title

      Journal of Surgical Oncology

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of simultaneous cholecystectomy and curative hepatic resection in patients with hepatocellular carcinoma

    • Author(s)
      Kaibori M, Kubo S, et al.
    • Journal Title

      Hepatogastroenterology

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 他インターフェロンSVRによるC型肝炎関連肝細胞癌切除例の再発抑制2013

    • Author(s)
      上西崇弘、久保正二, 他
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 5cm以下単発肝細胞癌に対する系統的切除の有用性の検証ーKASIOPEA(大阪府内5大学)からの報告ー2013

    • Author(s)
      廣川文鋭、久保正二、他
    • Organizer
      第25回日本肝胆膵外学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2013-06-12
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of interferon therapy for the treatment of hepatitis C virus-related hepatocellular carcinoma2013

    • Author(s)
      Kubo S
    • Organizer
      The 8th International Meeting of Hepatocellular Carcinoma : Eastern and Western Experiences
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-02-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌術後10年間無再発のための術前および術後血小板数維持の意義2012

    • Author(s)
      海堀昌樹、久保正二、他
    • Organizer
      第16回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2012-09-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 超高齢者の肝細胞癌に対する切除成績の検討2012

    • Author(s)
      野沢彰紀、久保正二、他
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山
    • Year and Date
      2012-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] B型関連単発肝癌根治治療後の核酸アナログ製剤による再発抑制効果と生命予後に関する検討2012

    • Author(s)
      浦田順久、久保正二、他
    • Organizer
      第48回日本肝臓学会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患に合併した肝細胞癌根治切除後の再発危険因子に関する検討2012

    • Author(s)
      金田和久、久保正二、他
    • Organizer
      第48回日本肝臓学会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌集学的治療の現況と再発予防ー外科医の立場から2012

    • Author(s)
      久保正二、他
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 背景因子を考慮した肝細胞癌に対する総合的治療戦略2012

    • Author(s)
      久保正二、他
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-04-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 多発肝細胞癌に対する肝切除の適応2012

    • Author(s)
      久保正二、他
    • Organizer
      第48回日本肝臓学会
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] C型肝炎関連肝細胞癌の外科治療における糖尿病の意義2012

    • Author(s)
      金田和久、上西崇弘、竹村茂一、久保正二
    • Organizer
      第96回 日本消化器病学会近畿支部例会
    • Place of Presentation
      大阪国際交流センター(大阪府)
    • Related Report
      2011 Research-status Report
  • [Presentation] HCV関連肝細胞癌の切除後再発および再々発におよぼすインターフェロン療法の影響2012

    • Author(s)
      栄 政之、久保正二、竹村茂一、坂田親治、上西崇弘、高台真太郎、新川寛二、浦田順久、大畑和則、金田和久、西岡孝芳、野沢彰紀、末廣茂文
    • Organizer
      第463回 大阪市医学会例会
    • Place of Presentation
      大阪市立大学医学部(大阪府)
    • Related Report
      2011 Research-status Report
  • [Presentation] Response to interferon therapy affects risk factors for postoperative recurrence of hepatitis C virus-related hepatocellular carcinoma2011

    • Author(s)
      Uenishi T, Kubo S, et al.
    • Organizer
      21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO2011)
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Features of recurrence-free survival for more than 10 years after liver resection for hepatocellular carcinoma2011

    • Author(s)
      Ohata K, Kubo S, et al.
    • Organizer
      21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO2011)
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Efficacy of antiviral therapy after liver resection for hepatitis B virus-related hepatocellular carcinoma2011

    • Author(s)
      Urata Y, Kubo S, et al.
    • Organizer
      International Surgical Week
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Risk factors for postoperative recurrence of hepatocellular carcinoma in patients with nonalcoholic fatty liver disease2011

    • Author(s)
      Kaneda K, Kubo S, et al.
    • Organizer
      International Surgical Week
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Impact of interferon therapy on first and second recurrence of hepatitis C virus-related hepatocellular carcinoma2011

    • Author(s)
      Sakae M, Kubo S, et al.
    • Organizer
      International Surgical Week
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] インターフェロン治療SVR後に発生したC型肝炎関連肝細胞癌切除例の検討2011

    • Author(s)
      上西崇弘、久保正二、他
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡
    • Year and Date
      2011-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己免疫性肝炎を合併した肝細胞癌に対して肝切除術を施行した7例の検討2011

    • Author(s)
      金田和久、久保正二、他
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡
    • Year and Date
      2011-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌切除後10年無再発経過後の肝癌再発症例の検討2011

    • Author(s)
      海堀昌樹、久保正二、他
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡
    • Year and Date
      2011-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] NBNC型肝細胞癌切除例の臨床像, 切除成績および再発危険因子の検討2011

    • Author(s)
      金田和久、竹村茂一、上西崇弘、清田誠志、新川寛二、浦田順久、栄 政之、大畑和則、野沢彰紀、山本隆嗣、久保正二
    • Organizer
      第47回 日本肝臓学会総会
    • Place of Presentation
      ホテル グランパシフィック LE DAIBA(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 高齢者における肝細胞癌に対する肝切除術の妥当性2011

    • Author(s)
      上西崇弘、竹村茂一、清田誠志、新川寛二、金田和久、栄 政之、浦田順久、大畑和則、野沢彰紀、久保正二
    • Organizer
      第47回 日本肝臓学会総会
    • Place of Presentation
      ホテル グランパシフィック LE DAIBA(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] B型慢性肝炎関連肝細胞癌切除後成績に及ぼす核酸アナログ療法の効果2011

    • Author(s)
      浦田順久、竹村茂一、新川寛二、大畑和則、金田和久、栄 政之、野沢彰紀、清田誠志、上西崇弘、久保正二
    • Organizer
      第111回 日本外科学会定期学術集会
    • Place of Presentation
      紙上開催(第112巻 臨時増刊号(1.2))
    • Related Report
      2011 Research-status Report
  • [Presentation] HCV関連肝癌根治切除術後再発に対する治療選択2011

    • Author(s)
      上西崇弘、竹村茂一、新川寛二、金田和久、栄 政之、浦田順久、大畑和則、野沢彰紀、久保正二
    • Organizer
      第111回 日本外科学会定期学術集会
    • Place of Presentation
      紙上開催(第112巻 臨時増刊号(1.2))
    • Related Report
      2011 Research-status Report
  • [Presentation] 非アルコール性脂肪性肝疾患に合併した肝細胞癌根治切除後の再発危険因子に関する検討2011

    • Author(s)
      金田和久、上西崇弘、野沢彰紀、栄 政之、浦田順久、大畑和則、新川寛二、清田誠志、竹村茂一、山本隆嗣、久保正二
    • Organizer
      第111回 日本外科学会定期学術集会
    • Place of Presentation
      紙上開催(第112巻 臨時増刊号(1.2))
    • Related Report
      2011 Research-status Report
  • [Presentation] 非アルコール性脂肪性肝炎に合併した肝細胞癌切除後の再発および死亡危険因子に関する検討2011

    • Author(s)
      金田和久、竹村茂一、上西崇弘、清田誠志、新川寛二、浦田順久、栄 政之、大畑和則、山本隆嗣、久保正二
    • Organizer
      第66回 日本消化器外科学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] C型肝炎関連肝細胞癌切除後再発症例における再々発規定因子の検討2011

    • Author(s)
      栄 政之、上西崇弘、竹村茂一、坂田親治、浦田順久、大畑和則、金田和久、西岡孝芳、野沢彰紀、久保正二
    • Organizer
      第73回 日本臨床外科学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Efficacy of antiviral therapy after liver resection for hepatitis B virus-related hepatocellular carcinoma2011

    • Author(s)
      Urata Y, Kubo S, Takemura S, Uenishi T, Kodai S, Shinkawa H, Sakae M, Kaneda K
    • Organizer
      International Surgical Week 2011(第44回万国外科学会)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Risk factors for postoperative recurrence of hepatocellular carcinoma in patients with nonalcoholic fatty liver disease2011

    • Author(s)
      Kaneda K, Uenishi T, Takemura S, Kiyota S, Shinkawa H, Urata Y, Sakae M, Kubo S
    • Organizer
      International Surgical Week 2011(第44回万国外科学会)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Impact of interferon therapy on first and second recurrence of hepatitis C virus-related hepatocellular carcinoma2011

    • Author(s)
      Sakae M, Uenishi T, Kubo S, Takemura S, Kodai S, Shinkawa H, Urata Y, Kaneda K
    • Organizer
      International Surgical Week 2011(第44回万国外科学会)
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Surgical treatment for hepatocellular carcinomas with non- B non-C chronic hepatitis2011

    • Author(s)
      Yamamoto T, Tanaka S, Uenishi T, Ishihara K, Tsukamoto T, Kubo S, Hirohashi K, Ohno K
    • Organizer
      International Surgical Week 2011(第44回万国外科学会)
    • Place of Presentation
      (ポスター発表)パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Response to interferon therapy affects risk factors for postoperative recurrence of hepatitis C virus-related hepatocellular carcinoma2011

    • Author(s)
      Uenishi T, Takemura S, Sakata C, Sakae M, Kaneda K, Urata Y, Ohata K, Nozawa A, Kubo S
    • Organizer
      21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2011)
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Features of recurrence-free survival for more than 10 years after liver resection for hepatocellular carcinoma2011

    • Author(s)
      Ohata K, Uenishi T, Takemura S,Kiyota S, Shinkawa H, Urata Y, Kaneda K, Sakae M, Nozawa A, Kubo S
    • Organizer
      21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists(IASGO2011)
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 5cm以下単発肝細胞癌に対する系統的切除の有用性の検証

    • Author(s)
      廣川文鋭、久保正二、權 雅憲、永野浩昭、中居卓也、林 道廣、竹村茂一、海堀昌樹、松井康輔、米田浩二、石崎守彦、中多靖幸、内山和久
    • Organizer
      第25回日本肝胆膵外学会
    • Place of Presentation
      ホテル東日本宇都宮
    • Related Report
      2013 Annual Research Report
  • [Presentation] :インターフェロンSVRによるC型肝炎関連肝細胞癌切除例の再発抑制

    • Author(s)
      上西崇弘、竹村茂一、久保正二
    • Organizer
      第17回日本肝臓学会大会
    • Place of Presentation
      グランドプリンスホテル新高輪 国際館パミール
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝細胞癌切除症例における自己血輸血の有用性

    • Author(s)
      上西崇弘,山本隆嗣,竹村茂一,坂田親治,浦田順久,野沢彰紀,久保正二
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2013 Annual Research Report
  • [Presentation] インターフェロン著効後に発生した肝細胞癌と胆管細胞癌の二重原発性肝癌の1切除例

    • Author(s)
      新川寛二,竹村茂一,坂田親治,浦田順久,西岡孝芳,野沢彰紀,木下正彦,濱野玄弥,久保正二
    • Organizer
      第25回日本肝胆膵外学会
    • Place of Presentation
      ホテル東日本宇都宮
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝癌治療における腹腔鏡下肝切除の位置づけ

    • Author(s)
      廣川文鋭,久保正二,永野浩昭,中居卓也,海堀昌樹,林 道廣,朝隈光弘,米田浩二,井上善博,内山和久
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      シーガイアコンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝切除後胆汁漏の病態と治療

    • Author(s)
      久保正二
    • Organizer
      第26回日本外科感染症学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 術後経過から見たC型肝炎関連肝細胞癌に対するインターフェロン療法に意義

    • Author(s)
      栄 政之,上西崇弘,竹村茂一,坂田親治,浦田順久,大畑和則,金田和久,西岡孝芳,野沢彰紀,久保正二
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Research-status Report
  • [Presentation] C型肝炎関連肝細胞癌根治切除例において糖尿病および糖尿病治療が術後再発におよぼす影響

    • Author(s)
      金田和久,上西崇弘,竹村茂一,坂田親治,浦田順久,栄 政之,大畑和則,西岡孝芳,野沢彰紀,山本隆嗣,久保正二
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Research-status Report
  • [Presentation] C型慢性肝炎に対するIFN著効後肝細胞癌症例における著効後早期発癌例と後期発癌例の比較検討

    • Author(s)
      新川寛二,竹村茂一,上西崇弘,坂田親治,浦田順久,金田和久,栄 政之,大畑和則,西岡孝芳,野沢彰紀,久保正二
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Research-status Report
  • [Presentation] 背景因子を考慮した肝細胞癌に対する総合的治療戦略

    • Author(s)
      久保正二,竹村茂一,上西崇弘,坂田親治,浦田順久,大畑和則,金田和久,栄 政之,西岡孝芳,野沢彰紀
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Research-status Report
  • [Presentation] 肝細胞癌集学的治療の現況と再発予防ー外科医の立場から

    • Author(s)
      久保正二,竹村茂一,上西崇弘
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] 破裂肝細胞癌切除後の長期予後の検討

    • Author(s)
      野沢彰紀,竹村茂一,上西崇弘,坂田親治,浦田順久,大畑和則,金田和久,栄 政之,西岡孝芳,久保正二
    • Organizer
      第24回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2012 Research-status Report
  • [Presentation] 多発肝細胞癌に対する肝切除の適応

    • Author(s)
      久保正二,竹村茂一,上西崇弘,坂田親治,浦田順久,大畑和則,金田和久,栄 政之,西岡孝芳,野沢彰紀
    • Organizer
      第48回 日本肝臓学会総会
    • Place of Presentation
      石川県音楽堂(金沢)
    • Related Report
      2012 Research-status Report
  • [Presentation] 背景因子からみた肝細胞癌術後長期無再発生存戦略

    • Author(s)
      大畑和則,竹村茂一,久保正二
    • Organizer
      第48回 日本肝臓学会総会
    • Place of Presentation
      石川県音楽堂(金沢)
    • Related Report
      2012 Research-status Report
  • [Presentation] 非アルコール性脂肪性肝疾患に合併した肝細胞癌根治切除後の再発危険因子に関する検討

    • Author(s)
      金田和久,上西崇弘,野沢彰紀,栄 政之,浦田順久,大畑和則,西岡孝芳,坂田親治,竹村茂一,山本隆嗣,田中さやか,若狭研一,久保正二
    • Organizer
      第48回 日本肝臓学会総会
    • Place of Presentation
      石川県音楽堂(金沢)
    • Related Report
      2012 Research-status Report
  • [Presentation] B型関連単発肝癌根治療法後の核酸アナログ製剤による再発抑制効果と生命予後に関する検討

    • Author(s)
      浦田順久,竹村茂一,新川寛二,大畑和則,金田和久,栄 政之,野沢彰紀,西岡孝芳,坂田親治,清田誠志,上西崇弘,久保正二
    • Organizer
      第48回 日本肝臓学会総会
    • Place of Presentation
      石川県音楽堂(金沢)
    • Related Report
      2012 Research-status Report
  • [Presentation] C型肝炎およびNAFLD/NASHに合併した肝細胞癌に対する根治切除例の臨床像ならびに切除成績の検討

    • Author(s)
      金田和久,上西崇弘,竹村茂一,坂田親治,浦田順久,栄 政之,大畑和則,西岡孝芳,野沢彰紀,久保正二
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山国際会議場(富山)
    • Related Report
      2012 Research-status Report
  • [Presentation] 超高齢者の肝細胞癌に対する切除成績の検討

    • Author(s)
      野沢彰紀,上西崇弘,竹村茂一,坂田親治,浦田順久,大畑和則,金田和久,栄 政之,西岡孝芳,久保正二
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山国際会議場(富山)
    • Related Report
      2012 Research-status Report
  • [Presentation] 肝細胞癌術後10年間無再発のための術前および術後血小板数維持の意義

    • Author(s)
      海堀昌樹,久保正二,永野浩昭
    • Organizer
      第54回日本消化器病学会大会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Related Report
      2012 Research-status Report
  • [Presentation] 肝切除施行巨大肝細胞癌の臨床的特徴の変遷

    • Author(s)
      野沢彰紀,竹村茂一,上西崇弘,坂田親治,浦田順久,大畑和則,金田和久,栄 政之,西岡孝芳,久保正二
    • Organizer
      第10回日本消化器外科学会大会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Related Report
      2012 Research-status Report
  • [Book] Novel approaches to liver cancer treatment : Laproscopic liver resectionfor liver cancer2014

    • Author(s)
      A. Kanazawa, T. Tsukamoto, S. Kubo
    • Total Pages
      250
    • Publisher
      Future Sicence Group
    • Related Report
      2013 Annual Research Report
  • [Book] 肝癌診療Q&A:インターフェロンで肝癌の再発予防は可能ですか?2013

    • Author(s)
      久保正二
    • Publisher
      中外医学社担当部分
    • Related Report
      2013 Final Research Report
  • [Book] 診療ガイドラインに沿った肝がん治療の要点と盲点:術前治療(2)脾摘出2013

    • Author(s)
      上西崇弘、久保正二
    • Publisher
      PSE文光社担当部分
    • Related Report
      2013 Final Research Report
  • [Book] 肝癌診療Q&A2013

    • Author(s)
      久保正二
    • Total Pages
      313
    • Publisher
      中外医学社
    • Related Report
      2013 Annual Research Report
  • [Book] 科学的根拠に基づく肝癌診療ガイドライン 2013年版2013

    • Author(s)
      久保正二
    • Total Pages
      223
    • Publisher
      金原出版
    • Related Report
      2013 Annual Research Report
  • [Book] 消化器外科学レビュー20112011

    • Author(s)
      久保正二、竹村茂一
    • Publisher
      肝細胞癌総合医学社担当部分
    • Related Report
      2013 Final Research Report
  • [Book] 肝細胞癌2011

    • Author(s)
      久保正二、竹村茂一
    • Total Pages
      6
    • Publisher
      総合医学社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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