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The plakin family proteins can be therapeutic targets for intrahepatic cholangiocarcinoma

Research Project

Project/Area Number 23592001
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionHyogo Medical University

Principal Investigator

UYAMA Naoki  兵庫医科大学, 医学部, 講師 (70402873)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Jiro  兵庫医科大学, 医学部, 教授 (90199373)
IIMURO Yuji  兵庫医科大学, 医学部, 教授 (30252018)
HIRANO Tadamichi  兵庫医科大学, 医学部, 准教授 (90340968)
SATAKE Makoto  兵庫医科大学, 医学部, 助教 (70399153)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肝内胆管癌 / Plakin / 癌細胞 / 線維芽細胞 / Plakin / Plakin Family / 癌関連繊維芽細胞 / 増殖能 / 転移能 / 肝内胆管がん / 癌関連線維芽細胞
Outline of Final Research Achievements

Plakin Family consists of cytoskeletal proteins such as plectin , desmoplakin and so on. In this project, we investigated expression of plectin and desmoplakin in human intrahepatic cholangiocarcinoma (ICC) and their fuctions. Immunohistochemistry revealed that these proteins were expressed by cancer cells as well as fibroblasts. In addition, integrin alpha6 and beta4, binding proteins of plectin, and desmocollin desmoglein, binding proteins of desmoplakin, were also expressed by cancer cells. Gene depletion experiments with SiRNA for these proteins revealed that they did not regulate ICC celllines function, such as proliferaion ability, migration ability and ability for activating fibroblas.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] Angiogenesis is crucial for liver regeneration after partial hepatectomy.2013

    • Author(s)
      Uda Y, Hirano T, Son G, Iimuro Y, Uyama N, Yamanaka J, Mori A, Arii S, Fujimoto J.
    • Journal Title

      Surgery.

      Volume: Vol.153、No.1 Issue: 1 Pages: 70-77

    • DOI

      10.1016/j.surg.2012.06.021

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Primary epithelioid hemangioendothelioma of the retroperitoneum: report of a case.2012

    • Author(s)
      Iimuro Y, Nakai N, Asano Y, Uyama N, Suzumura K, Nakai M, Nakasho K, Kashiwagi T, Fujimoto J.
    • Journal Title

      Surg Today.

      Volume: 42(10) Issue: 10 Pages: 1026-1031

    • DOI

      10.1007/s00595-012-0173-1

    • NAID

      10031033044

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肝胆膵の線維化;研究と診療の最近の進歩 肝臓の線維化:研究の進歩 肝細胞癌,肝内胆管癌の間質を構成する細胞群の特徴2012

    • Author(s)
      宇山直樹、飯室勇二, 河田則文, 鈴村和大, 藤元治朗
    • Journal Title

      肝胆膵

      Volume: 65(2) Pages: 239-251

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway2012

    • Author(s)
      Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N, Fujimoto J.
    • Journal Title

      Laboratory Investigation

      Volume: 92(1) Issue: 1 Pages: 57-71

    • DOI

      10.1038/labinvest.2011.150

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cells2011

    • Author(s)
      Hoshikawa Y, Kanki K, Ashla AA, Arakaki Y, Azumi J, Yasui T, Tezuka Y, Matsumi Y, Tsuchiya H, Kurimasa A, Hisatome I, Hirano T, Fujimoto J, Kagechika H, Shomori K, Ito H, Shiota G.
    • Journal Title

      Cancer Science

      Volume: 102(5) Issue: 5 Pages: 934-941

    • DOI

      10.1111/j.1349-7006.2011.01889.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis2011

    • Author(s)
      Seki E, Park E, Fujimoto J.
    • Journal Title

      Hepatology Research

      Volume: 41(7) Issue: 7 Pages: 597-610

    • DOI

      10.1111/j.1872-034x.2011.00822.x

    • NAID

      10031144129

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Fascin, an actin bundlling protein, can be a novel marker of human hepatic stellate cells and may regulate functions of Hscs through FAK-PI3K-AKT pathway.2011

    • Author(s)
      Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Satake M, Okada T, Hirano T, Kuroda N, Fujimoto J.
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      Chicago
    • Related Report
      2011 Research-status Report
  • [Presentation] Impact of preoperative 3D hepatectomy simulation system for liver resection and transplantation: Application to various kind of liver resection procedure.2011

    • Author(s)
      Fujimoto J, Iimuro Y, Yada A, Kondo Y, Saito S, Sueoka H, Ohashi K.
    • Organizer
      46th Annual Congress of the European Society for Surgical Research
    • Place of Presentation
      Aachen
    • Related Report
      2011 Research-status Report
  • [Presentation] A novel small molecule inhibitor of FAK inhibits the ability of proliferation and invasion of human cholangiocarcinoma cell lines in vitro.2011

    • Author(s)
      Uyama N, Iimuro Y, Kuroda N, Hirano T, Okada T, Asano Y, Suzumura K, Fujimoto J.
    • Organizer
      International Surgical Week ISW 2011
    • Place of Presentation
      Yokohama
    • Related Report
      2011 Research-status Report
  • [Presentation] 肝内胆管癌組織におけるFAKの発現とその役割.2011

    • Author(s)
      宇山直樹, 飯室勇二, 近藤祐一, 鈴村和大, 吉田康彦, 佐竹真, 麻野泰包, 岡田敏弘, 平野公通, 黒田暢一, 藤元治朗.
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Expression of fascin in human non-cancerous liver and hepatocellular carcinoma and its function of hepatic stellate cells.2011

    • Author(s)
      Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N,
    • Organizer
      16th International Symposium on Cells of the Hepatic Sinusoid
    • Place of Presentation
      Florence
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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