| Project/Area Number |
23592002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Department of Clinical Research, National Hospital Organization Nagasaki Medical Center |
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Principal Investigator |
KAMOHARA Yukio 独立行政法人国立病院機構(長崎医療センター臨床研究センター), その他部局等, その他 (50325643)
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| Co-Investigator(Kenkyū-buntansha) |
藤岡 ひかる 国立病院機構長崎医療センター, 副院長 (00264226)
石橋 大海 国立病院機構長崎医療センター, 研究員 (80127969)
戸次 鎮宗 国立病院機構長崎医療センター, 医師 (50601431)
河田 則文 大阪市立大学, 医学研究院, 教授 (30271191)
吉里 勝利 大阪市立大学, 医学研究院, 教授 (20095516)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脂肪性肝炎 / 術後肝障害 / 細胞死 / cytokeratin 18 fragment / 脂肪肝の脆弱性 / 肝再生 / 組織修復 / 肝障害 |
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| Research Abstract |
We investigated an ability of tissue repair and regeneration in HCC-patients with Non-Alcoholic Steatohepatitis (NASH). In NASH patients with more lipid droplet, postoperative liver dysfunction was increased, but not influenced liver regeneration after liver resection. In those patients, blood cytokeratin fragments (M30, M65) were higher than other viral and alcoholic liver disease, suggesting fragility of background liver status. Thus, in NASH liver resection, severe surgical stress including extended resection should be avoided.
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