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Research of the impact of glucose dependent insurinotropic polypeptide on pancreatogenesis and on panreas cancer development

Research Project

Project/Area Number 23592006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKyoto University

Principal Investigator

KOIZUMI Masayuki  京都大学, 医学(系)研究科(研究院), その他 (90512351)

Co-Investigator(Kenkyū-buntansha) MASUI Toshihiko  京都大学, 医学研究科, 助教 (20452352)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsインクレチン / GIP / 膵癌 / 膵発生 / 発癌 / 糖尿病 / GLP-1
Research Abstract

There are several similarities between organogensis and carcinogenesis. In this study, we focused on one of the incretin family, GIP(glucose-dependent insulinotropic polypeptide) and analyzed the role of GIP on pancreatogenesis as well as on carcinogenesis of the panreas. Loss of GIP receptor in mouse embryo shows transition of the beta cell to the alpha cell in the developing pancreas, which implies GIP comittment on beta cell development. In the pancreatic cancer specimen, the expression of GIP receptor but not of GIP itself diminishes as the tumor develops from low grade PanIN to the authentic carcinoma. Moreover, the expression of GIP receptor concomitantly diminishes as the Pdx1 decreases in the pancreatic cancer. We previously reported Pdx1 tp be an unfavorable prognostic factor, and these results suggest that the GIP develops pancreatic cancer through Pdx1 during the initial stage of the pancreas carcrinogenesis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (29 results)

All 2014 2013 2012 2011

All Journal Article (11 results) (of which Peer Reviewed: 9 results) Presentation (16 results) Book (2 results)

  • [Journal Article] Expression of SOX9 in intraductal papillary mucinous neoplasms of the pancreas2014

    • Author(s)
      Meng F, Takaori K, Ito T, Masui T, Kawaguchi M, Kawaguchi Y, Uemoto S.
    • Journal Title

      Pancreas

      Volume: 43(1) Issue: 1 Pages: 7-14

    • DOI

      10.1097/mpa.0b013e3182a70b2f

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term survival after resection of pancreatic ductal adenocarcinoma with para-aortic lymph node metastasis : case report2013

    • Author(s)
      Masui T, Kubota T, Aoki K, Nakanishi Y, Miyamoto T, Nagata J, Morino K, Fukugaki A, Takamura M, Sugimoto S, Onuma H, Tokuka A.
    • Journal Title

      World J Surg Oncol

      Volume: 11(1) Issue: 1 Pages: 195-195

    • DOI

      10.1186/1477-7819-11-195

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delayed gastric emptying improved by straight stomach reconstruction with twisted anastomosis to the jejunum after pylorus-preserving pancreaticoduodenectomy (PPPD) in 118 consecutive patients at a single institution2012

    • Author(s)
      Masui T, Doi R, Kawaguchi Y, Uemoto S.
    • Journal Title

      Surg Today

      Volume: 42(5) Issue: 5 Pages: 441-6

    • DOI

      10.1007/s00595-011-0097-1

    • NAID

      10030621609

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The flow angle beneath the gastrojejunostomy in Roux-en-Y reconstruction after distal gastrectomy predicts delayed gastric emptying2012

    • Author(s)
      Masui T, Kubota T, Nakanishi Y, Aoki K, Sugimoto S, Takamura M, Takeda H, Hashimoto K, Tokuka A
    • Journal Title

      Gastric Cancer.

      Volume: 15 Issue: 3 Pages: 281-286

    • DOI

      10.1007/s10120-011-0107-4

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas2011

    • Author(s)
      Prasadan K, Koizumi M, Tulachan S, Shiota C, Lath N, Paredes J, Guo P, El-Gohary Y, Malek M, Shah S, Gittes GK.
    • Journal Title

      Diabetes

      Volume: 60(2) Issue: 2 Pages: 548-54

    • DOI

      10.2337/db09-0035

    • Related Report
      2013 Final Research Report
  • [Journal Article] Successful neoadjuvant treatment with radiochemotherapy and systemic chemotherapy for the locally advanced pancreatic head cancer : report of a case2011

    • Author(s)
      Masui T, Doi R, Ogawa K, Kami K, Machimoto T, Seo S, Kawaguchi Y, Egawa H, Matsugu Y, Uemoto S.
    • Journal Title

      Hepatogastroenterology

      Volume: 58(110-111) Pages: 1809-13

    • Related Report
      2013 Final Research Report
  • [Journal Article] A case of progressive digital ischemia after early withdrawal of gemcitabine and S-1 in a patient with systemic sclerosis2011

    • Author(s)
      Zaima C, Kanai M, Ishikawa S, Kawaguchi Y, Masui T, Mori Y, Nishimura T, Matsumoto S, Yanagihara K, Chiba T, Mimori T
    • Journal Title

      Jpn J Clin Oncol

      Volume: 41 Issue: 6 Pages: 803-6

    • DOI

      10.1093/jjco/hyr045

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive intraductal papillary mucinous neoplasm with para-aortic lymph node metastasis : report of a case2011

    • Author(s)
      Nagai K, Doi R, Koizumi M, Masui T, Kawaguchi Y, Yoshizawa A, Uemoto S.
    • Journal Title

      Surg Today

      Volume: 41(1) Issue: 1 Pages: 147-52

    • DOI

      10.1007/s00595-009-4210-7

    • NAID

      10027819028

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The distribution of atypical epithelium in main-duct type intraductal papillary mucinous neoplasms of the pancreas2011

    • Author(s)
      Ito T, Doi R, Yoshizawa A, Sakikubo M, Nagai K, Kida A, Koizumi M, Masui T, Kawaguchi Y, Manabe T, Uemoto S.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 18(2) Issue: 2 Pages: 241-6

    • DOI

      10.1007/s00534-010-0337-6

    • NAID

      10029286430

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine2011

    • Author(s)
      Kenichiro Furuyama, et al
    • Journal Title

      Nature Genetics

      Volume: 43 Issue: 1 Pages: 34-41

    • DOI

      10.1038/ng.722

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer2011

    • Author(s)
      Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, Nishimura T, Mori Y, Masui T, Kawaguchi Y, Yanagihara K, Yazumi S, Chiba T, Guha S, Aggarwal BB.
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 68(1) Issue: 1 Pages: 157-64

    • DOI

      10.1007/s00280-010-1470-2

    • NAID

      120003238951

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Prognostic factors for patients with borderline resectable pancreatic cancer after neoadjuvant chemotherapy2013

    • Author(s)
      T. Masui, R. Doi, Y. Kawaguchi, M.Mizumoto, Y Iwanaga, M.Kawaguchi, K. Takaori, S. Uemoto.
    • Organizer
      47th Annual Pancreas Club
    • Place of Presentation
      Orland, Florida
    • Year and Date
      2013-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 遠隔転移を伴った膵内分泌腫瘍症例に対する外科的介入の意義2013

    • Author(s)
      増井俊彦、水本雅己、川口道也、岩永康裕、高折恭一、上本伸二
    • Organizer
      第113回外科学会総会
    • Place of Presentation
      博多市、福岡県
    • Year and Date
      2013-04-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Borederline resectable膵癌に対する術前GEM/S1療法の成績2013

    • Author(s)
      増井俊彦、水本雅己、川口道也、岩永康裕、高折恭一、上本伸二
    • Organizer
      第25回肝胆膵外科学会定期集会
    • Place of Presentation
      宇都宮市、栃木
    • Related Report
      2013 Final Research Report
  • [Presentation] 再発形式から見た膵内分泌腫瘍に対するリンパ節郭清の妥当性2013

    • Author(s)
      増井俊彦、水本雅己、川口道也、岩永康裕、高折恭一、上本伸二
    • Organizer
      第68回消化器外科学会総会
    • Place of Presentation
      宮崎市、宮崎県
    • Related Report
      2013 Final Research Report
  • [Presentation] 再発形式からみた術前化学放射線療法の照射野の検討2013

    • Author(s)
      増井俊彦、水本雅己、川口道也、岩永康裕、高折恭一、上本伸二
    • Organizer
      第44回膵臓学会大会
    • Place of Presentation
      仙台市、宮城県
    • Related Report
      2013 Final Research Report
  • [Presentation] 非機能性神経内分泌腫瘍に対する再発因子の検討2013

    • Author(s)
      増井俊彦、水本雅己、川口道也、岩永康裕、高折恭一、上本伸二
    • Organizer
      第40回日本膵切研究会
    • Place of Presentation
      高松市、香川県
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵癌に対する術後補助化学療法の至適時期の検討2012

    • Author(s)
      増井俊彦、久保田豊成、青木恵子、中西保貴、杉本真一、高村通生、武田啓志、橋本幸直、徳家敦夫
    • Organizer
      第67回消化器外科学会総会
    • Place of Presentation
      名古屋市、愛知県
    • Year and Date
      2012-07-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 再発形式から見た膵癌神経廓清の意義2012

    • Author(s)
      増井俊彦、久保田豊成、青木恵子、中西保貴、杉本真一、高村通生、武田啓志、橋本幸直、徳家敦夫
    • Organizer
      第24回肝胆膵外科学会定期集会
    • Place of Presentation
      新宿、東京都
    • Year and Date
      2012-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵頭部癌におけるバイパス術に対する至適時期の検討2012

    • Author(s)
      増井俊彦、久保田豊成、青木恵子、中西保貴、杉本真一、高村通生、武田啓志、橋本幸直、徳家敦夫
    • Organizer
      第112回外科学会総会
    • Place of Presentation
      幕張、千葉県
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵頭部癌におけるバイパス術に対する至適時期の検討2012

    • Author(s)
      増井俊彦、久保田豊成、青木恵子、中西保貴、杉本真一、高村通生、武田啓志、橋本幸直、徳家敦夫
    • Organizer
      第112回外科学会総会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
  • [Presentation] 再発形式から見た膵癌神経廓清の意義2012

    • Author(s)
      増井俊彦、久保田豊成、青木恵子、中西保貴、杉本真一、高村通生、武田啓志、橋本幸直、徳家敦夫
    • Organizer
      第24回肝胆膵外科学会定期集会
    • Place of Presentation
      新宿
    • Related Report
      2012 Research-status Report
  • [Presentation] 膵癌に対する術後補助化学療法の至適時期の検討2012

    • Author(s)
      増井俊彦、久保田豊成、青木恵子、中西保貴、杉本真一、高村通生、武田啓志、橋本幸直、徳家敦夫
    • Organizer
      第67回消化器外科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] #16転移のある膵癌術後10年後のSMA周囲再発に対して再切除施行し得た1例2011

    • Author(s)
      増井俊彦、久保田豊成、青木恵子、中西保貴、杉本真一、高村通生、武田啓志、橋本幸直、徳家敦夫
    • Organizer
      第42回膵臓学会大会
    • Place of Presentation
      弘前市、青森県
    • Year and Date
      2011-07-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 残胃の形態から見た幽門側胃切除後のRoux stasis syndromeの検討2011

    • Author(s)
      増井俊彦、久保田豊成、青木恵子、中西保貴、杉本真一、高村通生、武田啓志、橋本幸直、徳家敦夫
    • Organizer
      第66回消化器外科学会総会
    • Place of Presentation
      名古屋市、愛知県
    • Year and Date
      2011-07-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌派生の肝癌肉腫の1例2011

    • Author(s)
      増井俊彦、渡邉栄一郎、中西保貴、久保田豊成、青木恵子、高村通生、杉本真一、武田啓志、徳家敦夫
    • Organizer
      第23回肝胆膵外科学会定期集会
    • Place of Presentation
      新宿、東京都
    • Year and Date
      2011-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 郭清度から見た膵頭十二指腸切除後脂肪肝発生因子の検討2011

    • Author(s)
      増井俊彦、土井隆一郎、川口義弥、小泉将之、高折恭一、上本伸二
    • Organizer
      第111回外科学会総会
    • Place of Presentation
      紙上
    • Year and Date
      2011-05-25
    • Related Report
      2013 Final Research Report
  • [Book] 肝転移した神経内分泌腫瘍の治療戦略-外科切除―2013

    • Author(s)
      増井俊彦、高折恭一、上本伸二
    • Publisher
      肝胆膵
    • Related Report
      2013 Final Research Report
  • [Book] 術前画像診断のポイントと術中の解剖認識2013

    • Author(s)
      増井俊彦、高折恭一、上本伸二
    • Total Pages
      68
    • Publisher
      臨床外科増刊号
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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