Identification of serum biomarkers for atrial fibrosis in patients with atrial fibrillation : clinical application in diagnosis and prognosis

• Project/Area Number: 23592038
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Yamaguchi University
• Principal Investigator: SUEHIRO Kotaro 山口大学, 医学部附属病院, 助教 (10569312)
• Co-Investigator(Kenkyū-buntansha): HAMANO Kimikazu 山口大学, 大学院医学系研究科, 教授 (60263787)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 心房線維化 / 心房細動

Research Abstract

The purpose of this study was to investigate whether the preoperative ratio of atrial natriuretic peptide (ANP) to brain natriuretic peptide (BNP) reflects atrial fibrosis and can be used to predict the maze procedure outcome. Atrial tissue samples taken during surgery were used to quantify interstitial fibrosis. Plasma samples were obtained before the operation and were analyzed for ANP and BNP levels. 23 patients who underwent the radial approach to the maze procedure combined with mitral valve surgery were included in this study and were divided into a sinus rhythm (SR) group and an atrial fibrillation (AF) group based on postoperative cardiac rhythm. The preoperative ANP-to-BNP ratio demonstrated a negative correlation with left atrial fibrosis (r=-0.69; p=0.003). Moreover, our findings demonstrate that the preoperative ANP-to-BNP ratio predicts the outcome of a maze procedure in patients with mitral valve disease and represents a new biomarker for atrial fibrosis.

Research Products

• [Journal Article] Significance of ultrasound examination of skin and subcutaneous tissue in secondary lower extremity lymphedema (2013)
  • Author(s): Suehiro K, Morikage N, Murakami M, Yamashita O, Samura M, Hamano K.
  • Journal Title: Ann Vasc Dis. Volume: 6(2) Pages: 180-8
  • NAID: 130004713577
  • Peer Reviewed
• [Journal Article] Ratio of preoperative atrial natriuretic peptide to brain natriuretic peptide predicts the outcome of the maze procedure in mitral valve disease (2013)
  • Author(s): Masafumi Sato
  • Journal Title: Journal of Cardiothoracic Surgery Volume: 8 Issue: 1 Pages: 1-7
  • DOI: 10.1186/1749-8090-8-32
  • Peer Reviewed
• [Journal Article] Putting a Class I Stocking over a Class I Stocking Does Not Make a Class II Stocking (2012)
  • Author(s): Suehiro K, Morikage N, Murakami M, Yamashita O, Samura M, Hamano K.
  • Journal Title: Ann Vasc Dis. Volume: 5(4) Pages: 435-8
  • NAID: 130004713558
  • Peer Reviewed
• [Journal Article] Elastic multilayer bandages for chronic venous insufficiency : features of our technique (2012)
  • Author(s): Suehiro K, Okada M, Yoshimura A, Morikage N, Murakami M, Yamashita O, Hamano K.
  • Journal Title: Ann Vasc Dis. Volume: 5(3) Pages: 347-51
  • NAID: 130004487966
  • Peer Reviewed
• [Journal Article] Interface pressures derived from oversize compression stockings (2012)
  • Author(s): Suehiro K, Morikage N, Murakami M, Yamashita O, Hamano K.
  • Journal Title: Ann Vasc Dis. Volume: 5(3) Pages: 342-6
  • NAID: 130004487967
  • Peer Reviewed
• [Journal Article] Late-onset primary intestinal lymphangiectasia successfully managed with octreotide : a case report (2012)
  • Author(s): Suehiro K, Morikage N, Murakami M, Yamashita O, Hamano K.
  • Journal Title: Ann Vasc Dis. Volume: 5(1) Pages: 96-9
  • NAID: 130004695425
  • Peer Reviewed
• [Presentation] 下肢廃用性浮腫および続発性リンパ浮腫の皮下超音波所見の相違 (2013)
  • Author(s): 末廣晃太郎、佐村誠、山下修、村上雅憲、森景則保、濱野公一
  • Organizer: 第54回日本脈管学会総会
  • Place of Presentation: 東京(ステーションコンファレンス東京)
  • Year and Date: 2013-10-10
• [Presentation] リンパ管シンチグラム所見の再検討～下肢リンパ浮腫重症度との関連～ (2013)
  • Author(s): 末廣晃太郎、佐村誠、山下修、村上雅憲、森景則保、濱野公一
  • Organizer: 第33回日本静脈学会総会
  • Place of Presentation: 倉敷(倉敷市芸文館)
  • Year and Date: 2013-06-28
• [Presentation] 術中症例における蛍光リンパ管造影による用手的リンパドレナージ経路の検討 (2013)
  • Author(s): 末廣晃太郎、佐村誠、山下修、村上雅憲、森景則保、濱野公一
  • Organizer: 第37回日本リンパ学会総会
  • Place of Presentation: 福岡(アクロス福岡)
  • Year and Date: 2013-06-14
• [Presentation] 下肢リンパ浮腫の皮膚・皮下超音波所見の意義 (2013)
  • Author(s): 末廣晃太郎、佐村誠、山下修、村上雅憲、森景則保、濱野公一
  • Organizer: 第41回日本血管外科学会学術総会
  • Place of Presentation: 大阪(大阪国際会議場)
  • Year and Date: 2013-05-29
• [Presentation] 慢性静脈不全に対する高伸縮包帯を用いた多重弾性包帯法～当院での工夫と圧迫特性～ (2012)
  • Author(s): 末廣晃太郎、山下修、村上雅憲、森景則保、濱野公一
  • Organizer: 第32回日本静脈学会総会
  • Place of Presentation: さいたま(大宮ソニックシティ)
  • Year and Date: 2012-06-06
• [Presentation] オーバーサイズの弾性ストッキングの圧迫圧の検討 (2012)
  • Author(s): 末廣晃太郎、山下修、村上雅憲、森景則保、濱野公一
  • Organizer: 第40回日本血管外科学会学術総会
  • Place of Presentation: 長野(長野ビックハット)
  • Year and Date: 2012-05-23