Treatment for severe heart failure using human plancenta derived mesenchymal cells and differentiation inducing molecule to myocardiocytes
| Project/Area Number |
23592047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIDA Naoko 慶應義塾大学, 医学部, 特任助教 (70360112)
KIMURA Takehiro 慶應義塾大学, 医学部, 特任助教 (20449002)
MIYOSHI Shunichiro 慶應義塾大学, 医学部, 講師(非常勤) (10296577)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 幹細胞 / 間葉系 / 細胞移植 / 低侵襲 / 内視鏡 / 心不全 / 移植・再生医療 / 再生医学 / 循環器・高血圧 / 重症心不全 / ヒト幹細胞 |
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| Research Abstract |
1)Establishment of cell implantation technique using pericardial endoscopy
In beagle dogs, pericardial endoscope was placed in pericardial space using Seldinger technique and the view in the pericardial space was afforded. Specialized technique to work in the small pericardial space, optimized devise, and tools for cell transplant to the epicardium were developed. Human plancenta derived mesenchymal cells were successfully implanted to the left ventricle of beagle dogs. Pacing wire implantation under pericardial endoscopic view was also performed.
To find factors to enhance differentiation to the cardiomyocyte from mesenchymal cells, several candidate molecules were verified.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Multidisciplinary approach to the treatment of cardiac AA amyloidosis and aortic stenosis due to Castleman's disease: A hybrid therapy withtocilizumab and aortic valve replacement.2014
Author(s)
Shirakawa K, Egashira T, Ieda M, Kawaguchi S, Okamoto K, Kudo M, Yokoyama K,Tsuruta H, Murata M, Mikami S, Anzai A, Hayashida K, Kohno T, Maekawa Y, Sano M, Yozu R, Fukuda K.
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Journal Title
Int J Cardiol
Volume: 173(2)
Related Report
Peer Reviewed
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[Journal Article] Theeffectiveness of rigid pericardialendoscopy for minimally invasiveminor surgeries: Cell transplantation,epicardial pacemaker leadimplantation, and epicardial ablation2012
Author(s)
Takehiro Kimura, Shunichiro Miyoshi,Kazuma, Okamoto, Kojiro Tanimoto,Kotaro Fukumoto, Kyoko Soejima, SeijiTakatsuki, Keiichi Fukuda
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Journal Title
J Cardiothorac Surg
Volume: 7
Issue: 1
Pages: 117-117
DOI
Related Report
Peer Reviewed
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[Presentation] Non-Resectional Mitral Valve Repair for Barlow's Type Pathology(VIDEO)2013
Author(s)
H.Kitahara, K.Okamoto, M.Kudo, A.Hirano, S.Kawaguchi, H.Takaki, H.Haida, T.Ito,Y.Inaba, R.Yozu.
Organizer
American Association for Thoracic Surgery, 2013 MITRAL CONCLAVE
Place of Presentation
ニューヨーク<アメリカ）
Related Report
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