| Project/Area Number |
23592068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAGAYASU Takeshi 長崎大学, 医歯(薬)学総合研究科, 教授 (80284686)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Naoya 長崎大学, 准教授 (70404217)
TSUCHIYA Tomoshi 長崎大学, 大学院医歯薬学総合研究科, 講師 (30437884)
MIYAZAKI Takuro 長崎大学病院, 助教 (00584749)
及川 将弘 独立行政法人国立病院機構(九州がんセンター臨床研究センター), 乳腺科, 医師 (90612416)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 同時多発肺癌 / 肺内転移 / 原発多発肺癌 / 染色体構造変化 / array CGH |
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| Research Abstract |
We performed molecular analysis of 12 synchronous double lung cancer patients without lymph node metastasis (intrapulmonary metastasis in the same lobe (pm1): n=6, primary: n=6). We then evaluated the clinical outcomes of patients with pathologically diagnosed synchronous double lung cancers (intrapulmonary metastasis (pm): n=80, primary: n=39) and other T3 tumors (n=230). Examination of the concordance rate (CR) of the copy number changes (CNCs) for paired tumors showed that the metastasis group was larger than the primary group (55.5% vs. 19.6%, p=0.04). Pathological diagnosis and molecular classification were the same in 10 out of 12 cases (83%). Both pathological and molecular assessment using aCGH adapted in the current study appeared to have a consistency.
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