Establishment of therapeutic strategy for synchronous double lung cancers based on molecular analysis

• Project/Area Number: 23592068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Nagasaki University
• Principal Investigator: NAGAYASU Takeshi 長崎大学, 医歯(薬)学総合研究科, 教授 (80284686)
• Co-Investigator(Kenkyū-buntansha): YAMASAKI Naoya 長崎大学, 准教授 (70404217) ; TSUCHIYA Tomoshi 長崎大学, 大学院医歯薬学総合研究科, 講師 (30437884) ; MIYAZAKI Takuro 長崎大学病院, 助教 (00584749) ; 及川 将弘 独立行政法人国立病院機構(九州がんセンター臨床研究センター), 乳腺科, 医師 (90612416)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 同時多発肺癌 / 肺内転移 / 原発多発肺癌 / 染色体構造変化 / array CGH

Research Abstract

We performed molecular analysis of 12 synchronous double lung cancer patients without lymph node metastasis (intrapulmonary metastasis in the same lobe (pm1): n=6, primary: n=6). We then evaluated the clinical outcomes of patients with pathologically diagnosed synchronous double lung cancers (intrapulmonary metastasis (pm): n=80, primary: n=39) and other T3 tumors (n=230). Examination of the concordance rate (CR) of the copy number changes (CNCs) for paired tumors showed that the metastasis group was larger than the primary group (55.5% vs. 19.6%, p=0.04). Pathological diagnosis and molecular classification were the same in 10 out of 12 cases (83%). Both pathological and molecular assessment using aCGH adapted in the current study appeared to have a consistency.

Research Products

• [Journal Article] Clinical and molecular analysis of synchronous double lung cancers (2012)
  • Author(s): Junichi Arai, Tomoshi Tsuchiya, Masahiro Oikawa, Koji Mochinaga, Tomayoshi Hayashi, Koh-ichiro Yoshiura, Kazuhiro Tsukamoto, Naoya Yamasaki, Keitaro Matsumoto, Takuro Miyazaki, Takeshi Nagayasu
  • Journal Title: Lung Cancer Volume: 77 Pages: 281-287
  • NAID: 120006985469
• [Presentation] 同時多発肺腫瘍のarray-comparative-genomic-hybridization(aCG H)を用いた細胞遺伝学的検索と予後解析 (2012)
  • Author(s): 荒井淳一、及川将弘、土谷智史、宮崎拓郎、松本桂太郎、山崎直哉、林徳眞吉、吉浦孝一郎、永安武
  • Organizer: 第29回日本呼吸器外科学会
  • Place of Presentation: 秋田キャッスルホテル
  • Year and Date: 2012-05-18
• [Presentation] 同時多発肺腫瘍のarray-comparative-genomic-hybridization(aCGH)を用いた細胞遺伝学的検索と予後解析 (2012)
  • Author(s): 荒井淳一
  • Organizer: 第29回日本呼吸器外科学会
  • Place of Presentation: 秋田キャッスルホテル