| Project/Area Number |
23592075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
SEKINE YASUO 東京女子医科大学, 医学部, 教授 (70312957)
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| Co-Investigator(Kenkyū-buntansha) |
HIROSHIMA Kenzo 東京女子医科大学, 医学部, 教授 (80218833)
KATSURA Hideki 東京女子医科大学, 医学部, 教授 (20277213)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肺癌 / 慢性閉塞性肺疾患 / スクリーニング / 外科治療 / 肺気腫 / 発癌 / Driver oncogene |
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| Research Abstract |
We reviewed the mechanism of lung cancer from COPD. In the inflammatory micro-environment, bronchial epithelium and alveoli are destroyed. During the repair of these injured cells, broncho-alveolar stem cells (BASC) are activated and genetic mutation was introduced to lead carcinogenesis. In this phenomenon, activation of signal transducers, such as NF-kB and STAT3, are induced and contributed to carcinogenesis. We collected clinical data of approximately 1400 lung cancer patients who received surgical resection, and classified into four groups of COPD severity according to preoperative spirometry. Non-COPD and mild COPD patients had more adenocarcinomas, whereas moderate to severe COPD patients had more squamous cell carcinomas.
We conducted COPD screening by using community-based lung cancer screening program. Approximately 4% of attendance were suspected COPD and 25% of these were diagnosed COPD by spirometry.
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