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2013 Fiscal Year Final Research Report

Challenge for early detection of lung cancer and investigation of carcinogenesis in patients with COPD

Research Project

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Project/Area Number 23592075
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

SEKINE YASUO  東京女子医科大学, 医学部, 教授 (70312957)

Co-Investigator(Kenkyū-buntansha) HIROSHIMA Kenzo  東京女子医科大学, 医学部, 教授 (80218833)
KATSURA Hideki  東京女子医科大学, 医学部, 教授 (20277213)
Project Period (FY) 2011 – 2013
Keywords肺癌 / 慢性閉塞性肺疾患 / スクリーニング / 外科治療
Research Abstract

We reviewed the mechanism of lung cancer from COPD. In the inflammatory micro-environment, bronchial epithelium and alveoli are destroyed. During the repair of these injured cells, broncho-alveolar stem cells (BASC) are activated and genetic mutation was introduced to lead carcinogenesis. In this phenomenon, activation of signal transducers, such as NF-kB and STAT3, are induced and contributed to carcinogenesis. We collected clinical data of approximately 1400 lung cancer patients who received surgical resection, and classified into four groups of COPD severity according to preoperative spirometry. Non-COPD and mild COPD patients had more adenocarcinomas, whereas moderate to severe COPD patients had more squamous cell carcinomas.
We conducted COPD screening by using community-based lung cancer screening program. Approximately 4% of attendance were suspected COPD and 25% of these were diagnosed COPD by spirometry.

  • Research Products

    (18 results)

All 2014 2013 2012 2011

All Journal Article (12 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Detection of chronic obstructive pulmonary disease in community-based annual lung cancer screening : Chiba COPD lung cancer screening study group2014

    • Author(s)
      Sekine Y, Fujisawa T, Suzuki K, Tsutatani S, Kubota K, Ikegami H, Isobe Y, Nakamura M, Takiguchi, Y, Tatsumi K
    • Journal Title

      Respirology

      Volume: 19 Pages: 98-104

  • [Journal Article] The impact of combined pulmonary fibrosis and chronic obstructive pulmonary disease on long-term survival after lung cancer surgery2014

    • Author(s)
      Sekine Y, Sakairi Y, Yoshino M, Koh E, Hata A, Suzuki H, Yoshino I
    • Journal Title

      Thorac Cardiovasc Surg

      Volume: (in press)

    • DOI

      10.1055/s-0033-1363478

  • [Journal Article] Surveillance of chronic obstructive pulmonary disease in high-risk individuals by using regional lung-cancer mass screening2014

    • Author(s)
      Sekine Y, Yanagihori R, Suzuki K, Sugiyama S, Yamaji H, Ishibashi M, Fujisawa T
    • Journal Title

      Int J COPD

      Volume: (in press)

  • [Journal Article] CT検診と今後の展望2014

    • Author(s)
      関根康雄
    • Journal Title

      呼吸器内科

      Volume: (in press)

  • [Journal Article] Severity of chronic obstructive pulmonary disease and its relationship to lung cancer prognosis after surgical resection2013

    • Author(s)
      Sekine Y, Suzuki H, Yamada Y, Koh E, Yoshino I
    • Journal Title

      Thorac Cardiovasc Surg

      Volume: 61(2) Pages: 124-30

  • [Journal Article] 肺線維症と慢性閉塞性肺疾患の合併が肺癌手術成績に及ぼす影響2013

    • Author(s)
      関根康雄,坂入祐一,鈴木秀海,芳野充,黄英哲,吉野一郎
    • Journal Title

      肺癌

      Volume: 53 Pages: 7-11

  • [Journal Article] 肺がん検診を生かしたCOPDの早期発見2013

    • Author(s)
      関根康雄,藤澤武彦,鈴木公典
    • Journal Title

      日本医事新報

      Volume: 4643 Pages: 24-29

  • [Journal Article] Simple and effective technique for identification of intersegmental planes by infrared thoracoscopy after transbronchial injection of indocianine green2012

    • Author(s)
      Sekine Y, Koh E, Oishi H, Miwa M.A
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 143(6) Pages: 1330-5

  • [Journal Article] Early detection of COPD is important for lung cancer surveillance2012

    • Author(s)
      Sekine Y, Katsura H, Koh E, Hiroshima K, Fujisawa T
    • Journal Title

      Eur Resp J

      Volume: 39 Pages: 1230-40

  • [Journal Article] 呼吸ケアの最近の進歩低肺機能患者の周術期管理と呼吸2012

    • Author(s)
      関根康雄
    • Journal Title

      ケア呼吸器内科

      Volume: 22 Pages: 399-405

  • [Journal Article] 低肺機能肺がん患者に対する外科治療の進歩–術式の工夫、周術期管理と呼吸ケア-2012

    • Author(s)
      関根康雄,黄英哲,有村健,長谷川瑞江,桂秀樹
    • Journal Title

      日本呼吸ケアリハビリテーション学会誌

      Volume: 22 Pages: 309-312

  • [Journal Article] Innovative technique of transbronchial radiofrequency ablation for intrapulmonary tumors A preliminary study in a rabbit model2011

    • Author(s)
      Sekine Y, Suzuki H, Saito K, Nakajima T, Sakairi Y, Yoshida S, Yoshino I
    • Journal Title

      J Bronchol Intervent Pulmonol

      Volume: 18 Pages: 211-217

  • [Presentation] The impact of combined pulmonary fibrosis and chronic obstructive pulmonary disease on long-term survival after lung cancer surgery2013

    • Author(s)
      Sekine Y, Sakairi Y, Suzuki H, Yoshino M, Koh E, Yoshino I
    • Organizer
      International Association for Study of Lung Cancer Sydney
    • Place of Presentation
      Australia
    • Year and Date
      20130000
  • [Presentation] COPDからの発癌機序とCOPD/肺癌早期発見の意義2013

    • Author(s)
      関根康雄
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-05
  • [Presentation] A simple and effective technique for identification of intersegmental planes by infrared thoracoscopy after transbronchial injection of indocianine green2012

    • Author(s)
      Sekine Y, Koh E, Oishi H, Miwa M
    • Organizer
      20th European Conference on General Thoracic Surgery
    • Place of Presentation
      Essen, Germany
    • Year and Date
      20120000
  • [Presentation] The efficacy of COPD detection by utilizing a community-based annual screening program for lung cancer2012

    • Author(s)
      Sekine Y, Suzuki K, Kubota K, Ikegami H, Isobe Y, Nakamura M, Takiguchi Y, Tatsumi K, Fujisawa T
    • Organizer
      European Respiratory Society Annual Congress Vienna
    • Place of Presentation
      Eeu Resp J
    • Year and Date
      20120000
  • [Presentation] The impact of COPD on perioperative condition and long-term outcomes for patients with lung cancer2011

    • Author(s)
      Sekine Y, Katsura H, Koh E
    • Organizer
      Aspen Lung Conference
    • Place of Presentation
      Aspen-Colorado
    • Year and Date
      20110000
  • [Book] 肺がん早期発見のためのCOPD早期発見Annual Review2014

    • Author(s)
      関根康雄
    • Total Pages
      165-170
    • Publisher
      中外医学社

URL: 

Published: 2015-07-16  

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