| Project/Area Number |
23592089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
KATO Hiroki 大阪大学, 医学(系)研究科(研究院), 助教 (20448054)
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| Co-Investigator(Kenkyū-buntansha) |
HATAZAWA Jun 大阪大学, 大学院医学系研究科, 教授 (70198745)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 脳・神経 / 分子イメージング / PET / SPECT / てんかん / 脳血管障害 / MRI |
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| Research Abstract |
Detection of epileptogenic foci in intractable epilepsy is most important for planning of operative therapy. Development of low-invasive and accurate method for diagnostic imaging is expected. We suggested, based on a previous pilot study conducted in a small number of patients, that MRI-based partial volume effect correction (PVC) in I-123 iomazenil brain SPECT improves the detectability of cortical epileptogenic foci. In the present study, the effectiveness of MRI-based PVC in I-123 iomazenil brain SPECT in improving the detection of cortical epileptogenic foci was established by the investigation conducted on a relatively large sample size. In addition, we established experimental environment to develop PET and/or MRI imaging methods for small animal models of cerebrovascular disease or epilepsy. We made chronic cerebral hypoperfusion model rats, and evaluated their cerebral blood flow, cerebral oxygen metabolism, and brain inflammation by using these imaging modalities.
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