Induction of hormone-secreting cells from pituitary stem cells

Research Project

Project/Area Number	23592121
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cerebral neurosurgery
Research Institution	Kyoto University
Principal Investigator	Hojo Masato 京都大学, 医学研究科, 非常勤講師 (60372588)
Co-Investigator(Kenkyū-buntansha)	KAGWYAMA Ryoichiro 京都大学, ウイルス研究所, 教授 (80224369) MIYAMOTO Susumu 京都大学, 医学研究科, 教授 (70239440)
Project Period (FY)	2011-04-28 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	下垂体 / Notch / bHLH / Hes1 / Hes5 / Math3 / NeuroD / Mash1 / 再生医療 / Notch-Hes / ES細胞
Outline of Final Research Achievements	The pituitary development requires the control of proliferation and differentiation of progenitors. Molecular mechanisms of adenohypophysis development are much better understood, but little is known about mechanisms that regulate neurohypophysis development. The aim of this study was to clarify the role of Hes genes, known as Notch effectors, in neurohypophysis development. We have found that Hes1 and Hes5 control not only maintenance of progenitor cells but also pituicyte versus neuron fate specification during neurohypophysis development.