Induction of hormone-secreting cells from pituitary stem cells
Project/Area Number |
23592121
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cerebral neurosurgery
|
Research Institution | Kyoto University |
Principal Investigator |
Hojo Masato 京都大学, 医学研究科, 非常勤講師 (60372588)
|
Co-Investigator(Kenkyū-buntansha) |
KAGWYAMA Ryoichiro 京都大学, ウイルス研究所, 教授 (80224369)
MIYAMOTO Susumu 京都大学, 医学研究科, 教授 (70239440)
|
Project Period (FY) |
2011-04-28 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 下垂体 / Notch / bHLH / Hes1 / Hes5 / Math3 / NeuroD / Mash1 / 再生医療 / Notch-Hes / ES細胞 |
Outline of Final Research Achievements |
The pituitary development requires the control of proliferation and differentiation of progenitors. Molecular mechanisms of adenohypophysis development are much better understood, but little is known about mechanisms that regulate neurohypophysis development. The aim of this study was to clarify the role of Hes genes, known as Notch effectors, in neurohypophysis development. We have found that Hes1 and Hes5 control not only maintenance of progenitor cells but also pituicyte versus neuron fate specification during neurohypophysis development.
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Report
(6 results)
Research Products
(2 results)