A study of the neural differentiation and neural function of human cranial bone marrow stromal cells cultured under simulated microgravity
| Project/Area Number |
23592127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YUGE Rui 広島大学, 医歯薬保健学研究院, 教授 (20263676)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | ヒト頭蓋骨骨髄間質細胞 / 微少重力環境 / 神経再生 / 間葉系幹細胞 / 骨髄間質細胞 / 脊髄損傷 / ヒト頭蓋骨間葉系幹細胞 / 微小重力環境 |
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| Research Abstract |
Human cranial bones are thought to originate from the cranial neural crest that plays important role for constructiong central nervous systems in the embryo. In this study, we have investigated human cranial bone marrow derived stem cell (hcBMSC) capacities for neural differentiation. We cultured BMSC under simulated microgravity conditions to facilitate functional recovery from neural injury.
We show that hcBMSC has potency to differentiate into neural lineages better than the BMSC deriverd from illiac bone, and would be a novel alternative source of autologous adult stem cells for neural regenerative therapy.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Interactive effects of cell therapy and rehabilitation realize the full potential of neurogenesis in brain injury model2013
Author(s)
Imura T., Matsumoto M., Fukazawa T., Khalesi E., Sun Y.N., Takeda M., Uwatoko H., Nakata K., Tanimoto K., Kajiume T., Kawahara Y., Yuge L
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Journal Title
Neurosci Lett
Volume: 555
Pages: 73-78
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Human cranial bone derived stem cells have multipotency and the remarkable capacity of neural differentiation
Author(s)
Uwatoko H., Mitsuhara T., Magaki T., Ookura Y., Nakata K., Matsumoto M., Fukazawa T., Imura T., Sun YN., Furukawa T., Kawahara Y., Kurisu K., Yuge L.
Organizer
11th International Society for Stem Cell Research (ISSCR)
Place of Presentation
Boston, MA, USA
Related Report
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[Presentation] ヒト骨髄間質細胞の神経分化誘導－頭蓋骨と腸骨での比較・検討－
Author(s)
上床裕之, 光原崇文, 大倉優之介, 松本昌也, 中田恭輔, 深澤賢宏, 猪村剛史, 孫 亜楠, Elham Khalesi, 古川拓馬, 河原裕美, 山口 智, 栗栖 薫, 弓削 類
Organizer
第48回日本理学療法学術大会
Place of Presentation
名古屋
Related Report
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[Presentation] 臨床応用に向けたヒト頭蓋骨由来骨髄間質細胞の多分化能の検討
Author(s)
大倉優之介, 松本昌也, 深澤賢宏, 猪村剛史, 孫 亜楠, 上床裕之, 中田恭輔, Elham Khalesi, 古川拓馬, 河原裕美, 光原崇文, 山口 智, 栗栖 薫, 弓削 類
Organizer
第48回日本理学療法学学術大会
Place of Presentation
名古屋
Related Report
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[Presentation] ヒト頭蓋骨間葉系幹細胞の神経分化
Author(s)
光原崇文, 籬 拓郎, 武田 正明, 山口智, 上床裕之, 松本昌也, 河原裕美,弓削類, 栗栖 薫
Organizer
第44回広島神経医科学研究会
Place of Presentation
広島大学医学部広仁会館
Related Report
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