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Study of cancer microenvironment in brain metastasis using circulating tumor cells

Research Project

Project/Area Number 23592133
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNagasaki University

Principal Investigator

TANAKA Kunihiko  長崎大学, 医歯(薬)学総合研究科, 准教授 (80380955)

Co-Investigator(Renkei-kenkyūsha) TOYODA Keisuke  長崎大学, 大学病院, 医員 (40597366)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脳転移 / 血中循環がん細胞 / がん微小環境
Research Abstract

The direct cause of death of cancer, which is the leading cause of death in Japanese, is metastasis. Above all, brain metastasis is developed by cancer cells' intravasating,extravasating, and proloferating in the brain. The purpose of our project was to investigate how the circulating tumor cells get into the brain, adapt to the microenvironment, and proliferate in the brain. We established highly-brain metastatic cancer cells which were expressing green fluorescent protein and succeeded in developing new system in which the brain microenvironment was reconstructed in vitro. Using the system, we clarified that different types of cancer cells showed the different ways of proliferating in the brain.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Cilostazol attenuates ischemia-reperfusion-induced blood-brain barrier dysfunction enhanced by advanced glycation endproducts via transforming growth factor-β1 signaling.2014

    • Author(s)
      Takeshita T, Nakagawa S, Tatsumi R, So G, Hayashi K, Tanaka K, Deli MA, Nagata I, and Niwa M.
    • Journal Title

      Molecular and Cellular Neurosciences

      Volume: 60 Pages: 1-9

    • DOI

      10.1016/j.mcn.2014.01.006

    • NAID

      120006986528

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte growth factor enhances the barrier function in primary cultures of rat brain microvascular endothelial cells.2014

    • Author(s)
      Yamada N, Nakagawa S, Horai S, Tanaka K, Deli MA, Yatsuhashi H, and Niwa M.
    • Journal Title

      Microvascular Research

      Volume: 92 Pages: 41-49

    • DOI

      10.1016/j.mvr.2013.12.004

    • NAID

      120006986529

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Initial contact of glioblastoma cells with existing normal brain endothelial cells strengthen the barrier function via fibroblast growth factor 2 secretion: A new in vitro blood-brain barrier model2013

    • Author(s)
      Keisuke Toyoda
    • Journal Title

      Cellular and Molecular Neurobiology

      Volume: 33 Issue: 4 Pages: 489-501

    • DOI

      10.1007/s10571-013-9913-z

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 腫瘍微小環境としての血液脳関門2013

    • Author(s)
      田中邦彦
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 腫瘍微小環境としての血液脳関門.2013

    • Author(s)
      田中 邦彦、豊田 啓介、中川 慎介、丹羽 正美.
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Initial contact of glioblastoma cells with existing normal brain endothelial cells strengthen the barrier function via fibroblast growth factor 2 secretion2012

    • Author(s)
      Kunihiko Tanaka
    • Organizer
      Cold Spring Harbor Meeting 2012 Blood-brain Barrier
    • Place of Presentation
      Cold Spring Harbor, USA
    • Year and Date
      2012-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] BBBキットを用いた脳転移形式の評価2012

    • Author(s)
      田中邦彦
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Initial contact of glioblastoma cells with existing normal brain endothelial cells strengthen the barrier function via fibroblast growth factor 2 secretion.2012

    • Author(s)
      Tanaka K, Toyoda K, Nakagawa S, and Niwa M.
    • Organizer
      Cold Spring Harbor Meeting 2012 Blood-Brain Barrier
    • Place of Presentation
      Cold Spring Harbor, U.S.A.
    • Related Report
      2012 Research-status Report
  • [Presentation] BBBキットを用いた脳転移形式の評価2012

    • Author(s)
      田中邦彦
    • Organizer
      第85回日本薬理学会年会(一般口演)
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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