Low-energy extracorporeal shock wave therapy promotes VEGF expression and neuroprotection and improves locomotor recovery after spinal cord injury
Project/Area Number |
23592153
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Tohoku University |
Principal Investigator |
OZAWA Hiroshi 東北大学, 医学(系)研究科(研究院), 准教授 (10312563)
|
Co-Investigator(Kenkyū-buntansha) |
ITO Kenta 東北大学, 大学院医学系研究科, 准教授 (50375086)
|
Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 脊髄損傷 / 体外衝撃波 / VEDF / 低出力体外衝撃波治療 |
Research Abstract |
The present study investigated whether the low-energy ESWT can increase VEGF expression to provide neuroprotective effect and enhance the locomotor recovery after SCI in rats. Adult female Sprague-Dawley rats were divided into four groups: Sham group (laminectomy only), Sham-SW group (ESWT applied after laminectomy), SCI group and SCI-SW group (ESWT applied after SCI). The low-energy ESWT was applied to the injured spinal cord 3 times a week for 3 weeks after SCI. The low-energy ESWT significantly reduced neuronal loss in damaged neural tissue. Furthermore, locomotor function was significantly improved in animals in SCI-SW group compared to SCI group after SCI. These results demonstrated that the low-energy ESWT enhanced neuroprotective effect of VEGF and improve locomotor recovery following SCI.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury2014
Author(s)
Kanno H, Pressman Y, Moody A, Berg R, Muir EM, Rogers JH, Ozawa H, Itoi E, Pearse DD, Bunge MB
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Journal Title
J Neuroscience
Volume: 29,34(5)
Pages: 1838-55
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Peer Reviewed
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[Journal Article] Extracorporeal shock wave therapy improves the walking ability of patients with peripheral artery disease and intermittent claudication2012
Author(s)
Serizawa F, Ito K, Kawamura K, Tsuchida K, Hamada Y, Zukeran T, Shimizu T, Akamatsu D, Hashimoto M, Goto H, M Watanabe T, Sato A, Shimokawa H, Satomi S
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Journal Title
Circ J
Volume: 76
Pages: 1486-93
NAID
URL
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Peer Reviewed
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[Presentation] Combination of engineered Schwann cell implants to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury2013
Author(s)
Kanno H, Pressman Y, Moody A, Berg R, Muir EM, Rogers JH, Ozawa H, Itoi E, Pearse DD, Bunge MB
Organizer
59th Annual Meeting of the Orthopaedic Research Society
Place of Presentation
San Antonio, United States
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