| Project/Area Number |
23592223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
IBA Kosuke 札幌医科大学, 医学部, 准教授 (60363686)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Toshihiko 札幌医科大学, 医学部, 教授 (70244366)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 細胞・組織 / 病理学 / 骨・軟骨代謝学 / 骨粗鬆症 / 疼痛 / ビスホスホネート |
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| Research Abstract |
The aim of this study was to evaluate skeletal pain associated with osteoporosis and to examine the inhibitory effect of bisphosphonate (BP) on the pain in ovariectomized (OVX) mice. We evaluated skeletal pain by examining pain-like behavior and immunohistochemical findings. Additionally, we assessed the effects of BP on those examinations. The OVX mice showed a decrease in pain threshold, and an increase in the number of c-Fos immunoreactive neurons in the spinal cord. BP caused an increase in pain threshold and inhibited c-Fos expression. Serum level of tartrate-resistant acid phosphatase 5b was significantly negative-correlated with pain threshold value. Furthermore, we found that an antagonist of transient receptor potential channel vanilloid subfamily member 1, an acid-sensing nociceptor, improved pain-like behavior in OVX mice. These results indicated that the inhibitory effect of BP on osteoclast function might contribute to improvement of skeletal pain in osteoporosis.
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