| Project/Area Number |
23592224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
SAITO Tomoyuki 横浜市立大学, 医学(系)研究科(研究院), 教授 (30170517)
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| Co-Investigator(Kenkyū-buntansha) |
KUMAGAI Ken 横浜市立大学, 医学部, 講師 (10468176)
KUSAYAMA Yoshihiro 横浜市立大学, 附属病院, 助教 (40618203)
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| Research Collaborator |
MUSCHLER George F Cleveland Clinic, Orthopaedic Research Center, Director
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 変形性関節症 / 関節マーカー / 変形性膝関節症 |
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| Research Abstract |
The purpose of this study is to elucidate pathogenesis of osteoarthritis and to evaluate therapeutic efficacy using joint markers. Clinical status and joint markers were improved by intra-articular injection of hyaluronic acid for patients with osteoarthritis of the knee. Reduction of IL-6 suggests inhibitory effect of hyaluronic acid on inflammation and IL-6 seems to be a novel joint marker to assess progression and therapeutic efficacy for osteoarthritis. Increased number of blood vessels was shown in synovial tissue and increased expressions of angiogenesis-related factors were investigated. These factors contributing to progression of osteoarthritis are also possible joint markers for osteoarthritis.
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