| Project/Area Number |
23592242
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Hirosaki University |
|---|
Principal Investigator |
KUSHIKATA Tetsuya 弘前大学, 医学(系)研究科(研究院), 准教授 (80250603)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIROTA Kazuyoshi 弘前大学, 医学研究科, 教授 (20238413)
吉田 仁 弘前大学, 医学(系)研究科(研究院), 講師 (00374843)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HITOSHI Yoshida 弘前大学, 医学研究科, 講師 (00374843)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 麻酔 / 睡眠障害 / 内因性NPS / 麻酔・手術後の睡眠、認知障害 / ノンレム睡眠 / レム睡眠 / 睡眠 |
|---|
| Research Abstract |
Sleep disturbance after anesthesia and surgery could affect post-operative prognosis. It may cause ischemic heart disease or cerebral hemorrhage; thus to treat the sleep disturbance is one of notable issue in current anesthetic practice. We examined whether several anesthetics affect on sleep-wakefulness related neuropeptide using rat. These include neuropeptide S (NPS) and orexin (OX) that are well-documented endogenous sleep-wakefulness related neuropeptide. Ketamine and propofol, which are widely used in clinical practice, modified content of them in the rat brain. NPS decreased anesthesia time by both anesthetics. In addition, a NPS receptor enhanced physiological sleep in rats. These results indicated that anesthetics affected the sleep-wakefulness related neuropeptide and the peptides modified anesthetic status. We propose, with these results, that to control endogenous sleep-wakefulness related neuropeptide could provide some solution how to treat the sleep disturbance.
|
