Intracellular signaling of proliferation and differentiation in vascular smooth muscle cells

• Project/Area Number: 23592247
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Gifu University
• Principal Investigator: KUMAZAWA Masahiko 岐阜大学, 医学部附属病院, 助教 (10303504)
• Co-Investigator(Kenkyū-buntansha): TANABE Kumiko 岐阜大学, 医学部附属病院, 講師 (30402209) ; IIDA Hiroki 岐阜大学, 医学部附属病院, 教授 (30159561)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 血管平滑筋細胞 / 動脈硬化 / 創傷治癒 / 静脈麻酔薬 / 細胞内情報伝達 / 血管新生 / 遊走 / AMPK / PDGF / 血管形成後再狭窄

Research Abstract

Intravenous anesthetics are used during the perioperative and/or postoperative period in critically ill patients. Intravenous anesthetics are firmly established to have direct effects on vascular smooth muscle cells. In the present study, we investigated the effects of intravenous anesthetics on PDGF-BB-induced VSMC migration and the mechanism. Our results strongly suggest that propofol or midazolam inhibits VSMC migration by PDGF-BB via suppression of p38 MAPK activation. Propofol or midazolam may affect VSMC function in critically ill patients.

Research Products

• [Journal Article] Differential effects of intravenous anesthetics on PDGF-BB-induced vascular smooth muscle cell migration (2014)
  • Author(s): Iida M, Tanabe K, Kozawa O, Iida H
  • Journal Title: Cell Physiol Biochem Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Adenosine monophosphate-activated protein kinase regulates platelet-derived growth factor-BB-induced vascular smooth muscle cell migration (2013)
  • Author(s): Iida M, Tanabe K, Matsushima-Nishiwaki R, Kozawa O, Iida H
  • Journal Title: Arch Biochem Biophys Volume: 530 Pages: 83-92
  • Peer Reviewed
• [Journal Article] Nicorandil protects pial arterioles from endothelial dysfunction induced by smoking in rat (2013)
  • Author(s): Iwata K, Iida H, Iida M, Takenaka M, Tanabe K, Fukuoka N, Uchida M
  • Journal Title: J Neurosurg Anesthesiol Volume: 25 Pages: 392-398
  • Peer Reviewed
• [Journal Article] Adenosine monophosphate-activated protein kinase regulates platelet-derived growth factor-BB-induced vascular smooth muscle cell migration (2013)
  • Author(s): Miki Iida, Kumiko Tanabe, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida
  • Journal Title: Archives of Biochemistry and Biophysics Volume: 530 Issue: 2 Pages: 83-92
  • DOI: 10.1016/j.abb.2012.12.019
  • Peer Reviewed
• [Journal Article] Preventive effect of varenicline on impairment of endothelial function in cerebral vessels induced by acute smoking in rats (2012)
  • Author(s): Iida M, Iida H, Takenaka M, Tanabe K, Iwata K
  • Journal Title: J Anesth Volume: 26 Pages: 928-931
  • NAID: 10031147432
  • Peer Reviewed
• [Presentation] Inhibitory effects of propofol or midazolam on PDGF-BB-induced vascular smooth muscle cell migration (2014)
  • Author(s): 飯田美紀、田辺久美子、飯田宏樹
  • Organizer: Euroanesthesia
  • Place of Presentation: Sweden
• [Presentation] Inhibitory effects of propofol or midazolam on PDGF-BB-induced vascular smooth muscle cell migration (2014)
  • Author(s): Miki IIda、Kumiko Tanabe、HIroki Iida
  • Organizer: Euroanaesthesia 2014
  • Place of Presentation: Sweden
• [Presentation] プロポフォールが周術期血管障害に与える影響-platelet-derived growth factor-BBによる血管平滑筋細胞の遊走能を指標にして- (2013)
  • Author(s): 飯田美紀、田辺久美子、飯田宏樹
  • Organizer: 日本麻酔科学会第60回学術集会
  • Place of Presentation: 札幌
• [Presentation] プロポフォールが周術期血管障害に与える影響－platelet-derived growth factor-BBによる血管平滑筋細胞の遊走能を指標にして－ (2013)
  • Author(s): 飯田美紀、田辺久美子、飯田宏樹
  • Organizer: 日本麻酔科学会第60回学術集会
  • Place of Presentation: 札幌
• [Presentation] Effects of topical and intravenous JM1232(-) on cerebrovascular reactivity in rats (2012)
  • Author(s): 岩田賢治、田辺久美子、飯田宏樹
  • Organizer: American Society of Anesthesiologists 2012 Annual Meeting
  • Place of Presentation: Washington
• [Presentation] Pial Arteriolar Vasoconstriction After Unclamping of Abdominal Aortic Cross-Clamp is Not Associated With Obvious Cerebral Endothelial Dysfunction (2012)
  • Author(s): 道野朋洋、熊沢昌彦、田辺久美子、飯田宏樹
  • Organizer: American Society of Anesthesiologists 2012 Annual Meeting
  • Place of Presentation: Washington