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The study on functions of opioid receptors expressed in T lymphocytes

Research Project

Project/Area Number 23592252
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKyoto University

Principal Investigator

SHODA Takehiro  京都大学, 医学(系)研究科(研究院), 助教 (60335263)

Co-Investigator(Kenkyū-buntansha) OKAMURA Tomio  滋賀医科大学, 医学部, 教授 (70152337)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords麻薬 / モルヒネ / Tリンパ球 / オピオイド / 免疫抑制 / 血管平滑筋 / オピオイド受容体 / T細胞 / 血管弛緩
Research Abstract

Narcotics have been reported to develop immunosuppression as one of their side effects, the mechanism of which might be involved in opioid receptors expressed on immune cells, such as T lymphocytes.
We have cloned before, from human T cell cDNA library, the cDNA encoding a splice variant of kappa opioid receptor, truncated at its amino terminus (termed as KOR4). The stable transformants of HEK293 cells heterologously transfected with KOR4 cDNA are now being constructed and characterization of KOR4 will be investigated. Moreover, we have demonstrated that, in human T lymphocytes and Jurkat cells, signaling pathways by T cell receptor stimulation would be alterd by morphine pretreatment. These results suggest that narcotics could change T cell functions and modulate immune systems.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2013 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Dual modulation of the T-cell receptor-activated signal transduction pathway by morphine in human T lymphocytes.2013

    • Author(s)
      溝田敏幸、辻川洋、正田丈裕、福田和彦
    • Journal Title

      J Anesth

      Volume: 27 Issue: 1 Pages: 80-87

    • DOI

      10.1007/s00540-012-1472-9

    • NAID

      10031165387

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphine induces DNA damage and P53 activation in CD3+ T cells.2009

    • Author(s)
      辻川洋、正田丈裕、溝 田 敏 幸 、福田和彦
    • Journal Title

      Biochim Biophys Acta

      Volume: 1790 Issue: 8 Pages: 793-799

    • DOI

      10.1016/j.bbagen.2009.04.011

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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