Association of epigenetic modulation in the TACR1 gene with opioid-induced nausea and vomiting

• Project/Area Number: 23592301
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Sapporo Medical University
• Principal Investigator: SUGINO Shigekazu 札幌医科大学, 医学部, 助教 (00423765)
• Co-Investigator(Renkei-kenkyūsha): YAMAKAGE Michiaki 札幌医科大学, 医学部, 教授 (70285005)
• Research Collaborator: HAYASE Tomo 札幌医科大学, 医学部, 助教 (20579007) ; TACHIBANA Shun-suke 札幌医科大学, 医学部, 大学院生 ; NAWA Yuko 札幌医科大学, 医学部, 助教 (90586794) ; MORIYA Hiroyuki 北海道薬科大学, 薬学部, 助教 (00337049)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: エピジェネティクス / 悪心嘔吐 / 遺伝子 / 麻酔 / 麻酔科学 / 国際情報交換 / エピジェネティックス

Research Abstract

We hypothesized that regulation of the TACR1 gene is involved in the individual differences in severity of postoperative nausea and vomiting (PONV). We examined CpG methylation of the promoter region of the TACR1 gene, which modulates NK1 receptor expression in both human blood and mouse the brain. The results of the current study showed that the level of methylation was inversely correlated with the intensity of PONV. This new finding may contribute to preoperative prediction of the severity of PONV in surgical patients.

Research Products

• [Journal Article] Single-nucleotide polymorphisms and copy number variations of the FCGR2A and FCGR3A genes in healthy Japanese subjects. (2014)
  • Author(s): Moriya H, Saito K, Helsby N, Hayashi N, Sugino S, Yamakage M, Sawaguchi T, Takasaki M, Takahashi M, Kurosawa N.
  • Journal Title: Biomed Rep. Volume: 2 Issue: 2 Pages: 265-269
  • DOI: 10.3892/br.2013.210
  • Peer Reviewed
• [Presentation] Oprm1 Gene Polymorphism Reduces DNA Methylation at the Upstream CpG Island in Male Patients. (2013)
  • Author(s): Shigekazu Sugino, M.D.,Ph.D., Tomo Hayase, M.D., Misako Higuchi, M.D., Yuko Nawa, M.D.,Ph.D., Yukihiro Kumeta, M.D.,Ph.D., Michiaki Yamakage, M.D., Ph.D.
  • Organizer: American Society of Anesthesiologists 2013
  • Place of Presentation: San Francisco, U.S.A
• [Presentation] Recovery of Postoperative Cognitive Function in Elderly Patients After a Long Duration of Desflurane Anesthesia. (2013)
  • Author(s): Satoshi Kazuma, M.D., Tomo Hayase, M.D., Michiko Osuda, M.D., Shigekazu Sugino, M.D.,Ph.D., Michiaki Yamakage, M.D.,Ph.D.
  • Organizer: American Society of Anesthesiologists 2013
  • Place of Presentation: San Francisco, U.S.A
• [Presentation] Genetic variation and epigenetic modification of TAcR1 gene are associated with postoperative nausea and vomiting in surgical patients (2012)
  • Author(s): Hayase T, Sugino S, Yamakage M
  • Organizer: The Annual Meeting of American Society of Human Genetics
  • Place of Presentation: 米国San Francisco
• [Presentation] Haplotypes in human TACR1 gene are associated with postoperative nausea and vomiting (2012)
  • Author(s): Hayase T, Sugino S, Tachibana S-S, Kumeta Y, Yamakage M
  • Organizer: The Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: 米国Washington D.C
• [Presentation] Genetic variation in human TACR1 gene is associated with postoperative nausea and vomiting (2011)
  • Author(s): Hayase T, Sugino S, Tachibana S-S, Satoh M, Yamakage M
  • Organizer: The Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: 米国Chicago