The role of ASICs in neuroprotection after spinal ischemia

Research Project

Project/Area Number	23592305
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Nagoya City University
Principal Investigator	KUSAMA NOBUYOSHI 名古屋市立大学, 医学(系)研究科(研究院), 講師 (60336691)
Co-Investigator(Kenkyū-buntansha)	SUGIURA Takeshi 名古屋市立大学, 大学院医学研究科, 講師 (20295611) SOBUE Kazuya 名古屋市立大学, 大学院医学研究科, 教授 (90264738)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	ASIC / 脊髄虚血
Research Abstract	Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. ASIC1a channels possess intersubunit Cl-binding sites in the extracellular domain, which are highly conserved between ASIC subunits. We found that anions modulate a variety of ASIC properties and are dependent on the subunit composition, and the mechanism of modulation for ASIC2a and ASIC3 is distinct from that of ASIC1a. We speculate that modulation of ASIC gating by Cl is a novel mechanism to sense shifts in extracellular fluid composition.