| Project/Area Number |
23592346
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NAKAMURA Terukazu 京都府立医科大学, 医学(系)研究科(研究院), 講師 (10381964)
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| Co-Investigator(Kenkyū-buntansha) |
MIKI Tsuneharu 京都府立医科大学, 医学研究科, 教授 (10243239)
KAWAUCHI Akihiro 滋賀医科大学, 医学研究科, 教授 (90240952)
MIKAMI Kazuya 京都府立医科大学, 医学研究科, 助教 (10291585)
HONGO Fumiya 京都府立医科大学, 医学研究科, 助教 (80291798)
UEDA Takashi 京都府立医科大学, 医学研究科, 助教 (50601598)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癌精巣抗原 / 精巣腫瘍 / SPAG4 / 腎癌 / HIF1 / Multiplex qPCR / 前立腺癌 |
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| Research Abstract |
We demonstrated that one of cancer testis antigens (CTAs), sperm associated antigen 4 (SPAG4), was highly up-regulated in cancer specimens from renal cell carcinoma (RCC) patients compared with adjacent normal renal tissues. In renal cancer cells, SPAG4 was induced by the treatment of HIF stabilizing agent, DFO, and this induction was blocked by the knockdown of HIF1 alpha. Finally, SPAG4 mRNA expression was inversely correlated with tumor grade and stage, and lower expression of SPAG4 mRNA was significantly associated with shorter progression-free time in patients with RCC. These results suggest that SPAG4 is HIF-regulated CTAs and may be a potential prognostic candidate for RCC. Further study is ongoing to evaluate the potential of SPAG4 as a prognostic marker for testicular tumor.
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