| Project/Area Number |
23592399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TAMURA Naoaki 浜松医科大学, 医学部附属病院, 助教 (90402370)
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| Co-Investigator(Kenkyū-buntansha) |
KANAYAMA Naohiro 浜松医科大学, 医学部, 教授 (70204550)
SUGIHARA Kazuhiro 浜松医科大学, 医学部, 准教授 (00265878)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 着床 / ヒト絨毛性ゴナドトロピン / 子宮内膜上皮細胞 / トロフィニン / 子宮内膜 / トロフォブラスト / hCG / MUC1 / 胎盤 / 子宮 |
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| Research Abstract |
Under hCG treatment, expression levels of trophinin was enhanced and MUC1 was decreased in Ishikawa cells, one of endometrial epithelial cell lines. These alternations were more remarkable under hCG and IL-1beta treatment. From the Microarray analysis, gene expression levels of ADM and KISS1R were decreased in Ishikawa cells under hCG treatment.Genetic splicing variants of trophinin existed in Ishikawa cells. This fact suggested that trophinin may coordinate its function by dominant negative manner in vivo.
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