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elucidate a role of the meconium in the fatal cause of the amniotic fluid embolism

Research Project

Project/Area Number 23592410
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNara Medical University

Principal Investigator

OI Hidekazu  奈良県立医科大学, 医学部, 准教授 (10283368)

Co-Investigator(Kenkyū-buntansha) 小林 浩  奈良県立医科大学, 医学部, 教授 (40178330)
野口 武俊  奈良県立医科大学, 医学部, 助教 (10464661)
常見 泰平  奈良県立医科大学, 医学部, 助教 (20599831)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords羊水塞栓症 / 羊水 / 胎便 / 分娩後異常母体出血 / SCC / Sialyl Tn / STN / 分娩時出血量
Research Abstract

The case that serum level of STN and CEA which were contained rich in meconium rose to after delivery was considered as the case that a meconium ingredient entered into the maternal circulation. The correlation between the difference in serum level of these tumor markers at the peripartum period and APPH was investigated statistically. And the correlation of each values of STN, CEA, C3, C4, FDP-DD in maternal serum in two groups with turbid amniotic fluid and clear amniotic fluid and APPH was investigated also. The result of making a study for the correlation between the difference of each values in maternal serum at peripartum period and APPH was not proved statistically. But the correlation between turbid amniotic fluid and APPH was observed significantly (P<0.05). The possibilities were suggested that when a large amount of turbid AF entered into maternal circulation, APPH will be occurred. This phenomenon will lead to the poor prognosis in the patients with amniotic fluid embolism.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (8 results) (of which Invited: 1 results)

  • [Journal Article] Predictor of mortality in patients with amnitoic fluid embolism2014

    • Author(s)
      Oi H.
    • Journal Title

      J Obstet Gyneacol Re

      Volume: 40 Issue: 4 Pages: 941-945

    • DOI

      10.1111/jog.12278

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of interleukin-6 (IL-6) and squamous cell carcinoma (SCC) as amniotic fluid-specific markers.2012

    • Author(s)
      Naruse K, Noguchi T, Yoshida S, Tsunemi T, Shigetomi H, Oi H, Kobayashi H
    • Journal Title

      Open Journal of Obstetrics and Gynecology

      Volume: 2 Issue: 02 Pages: 147-150

    • DOI

      10.4236/ojog.2012.22028

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Overview of amnitoic Fluid Embolism: Pst, Present and Future Directions2012

    • Author(s)
      Tsunemi T. Oi H. NOguchi T. Kobayashi H. et.al
    • Journal Title

      The Open Women's Health Journal

      Volume: 6 Issue: 1 Pages: 24-29

    • DOI

      10.2174/1874291201206010024

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The entry of fetal and amniotic fluid components into the uterine vessel circulation leads to sterile inflammatory processes during parturition.2012

    • Author(s)
      Kobayashi H.
    • Journal Title

      Front Immunol.2012;3:321

      Volume: 3 Pages: 1-6

    • DOI

      10.3389/fimmu.2012.00321

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Search for amniotic fluid-specific markers : Novel Biomarker Candidates for Amniotic Fluid Embolism2011

    • Author(s)
      ④Kobayashi H., Naruse K., Sado T., Noguchi K., Yoshida S., Shigetomi H., Onogi A., Oi H
    • Journal Title

      Open Women Health

      Volume: 5 Issue: 1 Pages: 7-15

    • DOI

      10.2174/1874291201105010007

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] amniotic fluid emboli updates2013

    • Author(s)
      Oi H
    • Organizer
      The 23th Asia and Oceanic Congress of Obstetrics and Gynaecology
    • Place of Presentation
      Thailand, Bangkok
    • Year and Date
      2013-10-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 羊水マーカーsquamous cell carcinogen antigen (SCC)を用いた羊水塞栓症の発症原因の解明2013

    • Author(s)
      大井豪一
    • Organizer
      第65回日本産科婦人科学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2013-05-11
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] amniotic fluid emboli updates2013

    • Author(s)
      Oi H.
    • Organizer
      The 23th Asia and Oceanic Congress of Obstetrics and Gynaecology
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 登録された羊水塞栓症例における症状別解析により本症の発症原因を探る2012

    • Author(s)
      大井豪一
    • Organizer
      第64回日本産科婦人科学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 登録された羊水塞栓症例における症状別解析より本症の発症原因を探る2012

    • Author(s)
      大井豪一
    • Organizer
      日本産科婦人科学会
    • Place of Presentation
      神戸ポートピアホテル
    • Related Report
      2012 Research-status Report
  • [Presentation] 致死的因子を含む割合が関連する羊水塞栓症における死亡率2011

    • Author(s)
      大井豪一
    • Organizer
      第63回日本産科婦人科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of amniotic fluid embolism between 1992-2006 in Japan2011

    • Author(s)
      大井豪一
    • Organizer
      日独血栓止血学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of amniotic fluid embolism between 1992-2006 in Japan2011

    • Author(s)
      大井 豪一
    • Organizer
      日独止血血栓学会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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