| Project/Area Number |
23592433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURACHI Hirohisa 山形大学, 医学部, 教授 (40153366)
YAMATANI Hizuru 山形大学, 医学部, 医員 (40550637)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | エストロゲン / 閉経 / 内臓肥満 / メタボリック症候群 / コルチゾール / メタボリックシンドローム / 脂肪酸 / 内臓脂肪 / グルココルチコイド / 11β-HSD1 |
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| Research Abstract |
The cortisol/cortisone ratio and the expression of 11beta-HSD1 mRNA in visceral fatin postmenopausal women were significantly higher than those in premenopausal women. There was a significant correlation between the E1/E2 ratio of visceral fat and body mass index in postmenopausal women. A significant correlation between the cortisol/cortisone ratio and the E1/E2 ratio of visceral fat was observed in postmenopausal women.The expression of 11beta-HSD1 mRNA in visceral fat increases in postmenopausal women, and the E1/E2 ratio in visceral fat may be associated with local glucocorticoid levels after menopause. The concentrations of fatty acid metabolites in the visceral fat of postmenopausal women were significantly higher than those in the visceral fat of premenopausal women. The change in fatty acid metabolism in visceral adipose tissues might be related to metabolic syndrome in postmenopausal women.
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