Establishment of cancer virotherapy and imaging system targeting cancer stem cells in gynecologic cancer.
Project/Area Number |
23592439
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
|
Research Institution | Kanazawa University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
KYO Satoru 金沢大学, 医学系, 准教 (50272969)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 癌幹細胞 / 末梢血中腫瘍細胞 / テロメラーゼ / がん幹細胞 / ウイルス療法 |
Research Abstract |
We have established telomerase-specific replication-selective adenoviruses (TRAD) which can replicate only in telomerase activated cells. In the present study, we assessed the effectiveness of TRAD to the candidates of cancer stem cells in gynecologic cancer. We have also developed a detection system for circulating tumor cells (CTCs) using GFP expressing TRAD. CTCs were detected in 40% of patients with gynecological malignancies. There was no significant correlation between CTC counts and tumor types or known clinicopathological factors, such as clinical stage and histological type. The CTCs rapidly vanished after surgery or chemotherapy in most patients whose treatments were effective. In contrast, the persistence of CTCs even after treatments was tightly associated with poor response to the treatments (P<0.005).
|
Report
(4 results)
Research Products
(26 results)
-
-
-
-
-
-
[Journal Article] Circulating tumor cells detected by a novel adenovirus-mediated system may be a potent therapeutic marker in gynaecological cancers2012
Author(s)
Takakura M, Kyo S, Nakamura M, Maida Y, Mizumoto Y, Bono Y, Zhang X, Hashimoto Y, Urata Y, Fujiwara T, Inoue M
-
Journal Title
Br J Cancer
Volume: 107(3)
Pages: 448-54
Related Report
Peer Reviewed
-
[Journal Article] Circulating tumour cells detected by a novel adenovirus-mediated system may be a potent therapeutic marker in gynaecological cancers.2012
Author(s)
Takakura M, Kyo S, Nakamura M, Maida Y, Mizumoto Y, Bono Y, Zhang X, Hashimoto Y, Urata Y, Fujiwara T, Inoue M.
-
Journal Title
Br J Cancer
Volume: 107
Issue: 3
Pages: 448-454
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-