| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The structures of sugar chains of hCG are quite different in trophoblastic neoplasia compared with normal pregnancy and hydatidiform mole, and it is because of N-acetylglucosaminyltransferase IVa (GnT-IVa)and core 2 beta-1, 6-N-acetylglucosaminyltransferase (C2GNT). The expression of GnT-IVa and C2GNT was strong in choriocarcinoma and invasive mole, but very weak in normal placenta and hydatidiform mole. The two glycosyltransferases involoved in promoting of invasion ability in choriocarcinoma. The result of immunoprecipitation suggested that Gnt-IVa promotes invasion ability via glycosylation of beta1 integrin. Luiferase assay suggested that cRel may regulate transcription of GnT-IVa via binding to the promoter of GnT-IVa.
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