• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Fundamental study evidencing relationship between tonsillar focal diseases and palatine tonsils

Research Project

Project/Area Number 23592518
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionAsahikawa Medical College

Principal Investigator

TAKAHARA Miki  旭川医科大学, 医学部, 講師 (50322904)

Co-Investigator(Kenkyū-buntansha) NAGATO Toshihiro  旭川医科大学, 医学部, 助教 (80431419)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords扁桃病巣疾患 / IgA腎症 / APRIL / CXCR3 / 咽頭科学 / 口蓋扁桃
Research Abstract

IgA nephropathy (IgAN) has a poor prognosis because of progress to end-stage renal failure over a period of 20 years. IgAN is famous for typical tonsillar focal diseases, and tonsillectomy has been reported to be effective for inhibition of the progression. Unfortunately, this fact was not widely known. We try to establish fundamental relationship between IgAN and palatine tonsils by immunological technique in order to enlighten other doctors about the effectiveness of tonsillectomy and clarify a factor which predict the effectiveness.
In this serious of examination, we found that APRIL(a proliferation-inducing ligand) was involved in hyper-production of IgA from the tonsils of IgAN patients, and that chemokine receptor CXCR3 on tonsillar T-cells was related to homing of T-cells to the lesions of glomerulus. These results indicate that tonsils are related to not only abnormality of IgA, but also T-cell homing. We will continue to study for further understanding of the relationships.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (40 results)

All 2014 2013 2012 2011 Other

All Journal Article (15 results) (of which Peer Reviewed: 3 results) Presentation (17 results) (of which Invited: 2 results) Book (6 results) Remarks (2 results)

  • [Journal Article] IgA腎症の病態における扁桃T細胞の役割2014

    • Author(s)
      高原幹
    • Journal Title

      口腔咽頭科、.まだインターネット上になし。

      Volume: 27 Pages: 25-28

    • NAID

      130005438071

    • Related Report
      2013 Final Research Report
  • [Journal Article] IgA腎症の病態における扁桃T細胞の役割2014

    • Author(s)
      高原 幹
    • Journal Title

      日本口腔・咽頭科学会雑誌

      Volume: 27 Pages: 2528-2528

    • NAID

      130005438071

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「耳鼻咽喉科における病巣感染症up date-扁桃・副鼻腔疾患を中心に-」扁桃病巣疾患に対する扁桃摘出術の適応と効果2012

    • Author(s)
      高原幹、原渕保明
    • Journal Title

      ENTONI

      Volume: 146 Pages: 32-42

    • NAID

      120005307974

    • URL

      http://ci.nii.ac.jp/naid/120005307974

    • Related Report
      2013 Final Research Report
  • [Journal Article] 「掌蹠膿疱症の治療-あの手この手」(Part3)病因と病態(総説06)扁桃と掌蹠膿疱症耳鼻科の立場から2012

    • Author(s)
      高原幹、原渕保明
    • Journal Title

      Visual Dermatology

      Volume: 11 Pages: 1042-1047

    • URL

      http://gakken-mesh.jp/journal/detail/9784780903355.html

    • Related Report
      2013 Final Research Report
  • [Journal Article] 「小児の耳鼻咽喉科108の疑問」口腔・咽頭疾患扁桃病巣疾患に口蓋扁桃摘出術は有効か?2012

    • Author(s)
      高原幹
    • Journal Title

      JOHNS

      Volume: 28 Pages: 448-450

    • URL

      http://www.tokyo-igakusha.co.jp/asset/contents/JOH2803.pdf

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【掌蹠膿疱症の治療-あの手この手】 (Part3)病因と病態 (総説06) 扁桃と掌蹠膿疱症 耳鼻科の立場から2012

    • Author(s)
      高原 幹
    • Journal Title

      Visual Dermatology

      Volume: 11 Pages: 1042-1047

    • Related Report
      2012 Research-status Report
  • [Journal Article] 【耳鼻咽喉科における病巣感染症up date-扁桃・副鼻腔疾患を中心に-】 扁桃病巣疾患に対す る扁桃摘出術の適応と効果2012

    • Author(s)
      高原 幹、原渕保明
    • Journal Title

      ENTONI

      Volume: 146 Pages: 32-42

    • NAID

      120005307974

    • Related Report
      2012 Research-status Report
  • [Journal Article] 他科からみた扁桃摘出術のクリニカルエビデンス 扁桃病巣疾患における扁桃摘出術についてのアンケート調査2012

    • Author(s)
      長門 利純、高原 幹、林 達哉、原渕 保明
    • Journal Title

      口腔・咽頭科

      Volume: 25 Pages: 61-71

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【小児の耳鼻咽喉科108の疑問】 口腔・咽頭疾患 扁桃病巣疾患に口蓋扁桃摘出術は有効か?2012

    • Author(s)
      高原 幹
    • Journal Title

      JOHNS

      Volume: 28 Pages: 448-450

    • Related Report
      2011 Research-status Report
  • [Journal Article] Clinical outcome of tonsillectomy for palmoplantar pustulosis and etiological relationship between palmoplantar pustulosis and tonsils2011

    • Author(s)
      Takahara M
    • Journal Title

      Adv Otorhinolaryngol

      Volume: 72 Pages: 86-88

    • DOI

      10.1159/000324618

    • ISBN
      9783805597227, 9783805597234
    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 扁桃の免疫機能と病態扁桃を中心としたIgA腎症の病態解明2011

    • Author(s)
      高原幹
    • Journal Title

      小児耳鼻咽喉科

      Volume: 3 Pages: 233-237

    • URL

      https://www.jstage.jst.go.jp/article/shonijibi/31/3/31_233/_article/-char/ja/

    • Related Report
      2013 Final Research Report
  • [Journal Article] 扁桃病巣感染症研究の最前線IgA腎症扁桃におけるIgA過剰産生とT細胞の関与2011

    • Author(s)
      高原幹
    • Journal Title

      口腔咽頭科

      Volume: 24 Pages: 87-90

    • URL

      http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=2011187208

    • Related Report
      2013 Final Research Report
  • [Journal Article] 「扁桃病巣感染症研究の最前線」 IgA腎症扁桃におけるIgA過剰産生とT細胞の関与2011

    • Author(s)
      高原 幹
    • Journal Title

      口腔咽頭科

      Volume: 24 Pages: 87-90

    • Related Report
      2011 Research-status Report
  • [Journal Article] 「基礎医学から」 扁桃病巣疾患の発症機序2011

    • Author(s)
      高原 幹
    • Journal Title

      日本医事新報

      Volume: 4527 Pages: 35-38

    • NAID

      40017440801

    • Related Report
      2011 Research-status Report
  • [Journal Article] 扁桃の免疫機能と病態 扁桃を中心としたIgA腎症の病態解明2011

    • Author(s)
      高原 幹
    • Journal Title

      小児耳鼻咽喉科

      Volume: 3 Pages: 233-237

    • Related Report
      2011 Research-status Report
  • [Presentation] APRIL plays important role in hyper-production of IgA by tonsillar lymphocytes obtained from IgA nephropathy patients2013

    • Author(s)
      高原幹, 他
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      千葉県幕張
    • Related Report
      2013 Final Research Report
  • [Presentation] Immunologic linkage between tonsil an2013

    • Author(s)
      Takahara M、et al
    • Organizer
      d IgA nephropathy. The 8th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways
    • Place of Presentation
      Zurich Switzerland.
    • Related Report
      2013 Final Research Report
  • [Presentation] Treatment outcome of tonsillectomy for patients with pustulotic arthro-osteitis (PAO).2013

    • Author(s)
      Takahara M、et al
    • Organizer
      The 134rd COSM
    • Place of Presentation
      Orlando USA
    • Related Report
      2013 Final Research Report
  • [Presentation] IgA腎症の病態における扁桃T細胞の役割2013

    • Author(s)
      高原 幹
    • Organizer
      日本口腔・咽頭科学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Immunologic linkage between tonsil and IgA nephropathy2013

    • Author(s)
      Takahara M
    • Organizer
      International Symposium on Tonsils and Mucosal Barriers of the Upper Airways
    • Place of Presentation
      Zulich, Switzerland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Treatment outcome of tonsillectomy for patients with pustulotic arthro-osteitis (PAO).2013

    • Author(s)
      Takahara M, Harabuchi Y
    • Organizer
      COSM
    • Place of Presentation
      Orlando,USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] IgA腎症患者におけるAPRILの検討2013

    • Author(s)
      高原幹、原渕保明
    • Organizer
      日本腎臓学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] APRIL plays important role in hyper-production of IgA by tonsillar lymphocytes obtained from IgA nephropathy patients2013

    • Author(s)
      Takahara M, Harabuchi Y
    • Organizer
      日本免疫学会
    • Place of Presentation
      千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] IgA腎症の病態における扁桃T細胞の役割2012

    • Author(s)
      高原幹
    • Organizer
      第26回日本口腔・咽頭科学会
    • Place of Presentation
      名古屋市.
    • Related Report
      2013 Final Research Report
  • [Presentation] 重症急性咽頭・扁桃炎におけるレボフロキサシン1日1回投与の有用性2012

    • Author(s)
      高原幹他
    • Organizer
      第55回日本化学療法学会西日本支部総会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] IgA腎症扁桃におけるAPRILとCXCR3の検討2012

    • Author(s)
      高原幹他
    • Organizer
      第30回耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      滋賀県大津市
    • Related Report
      2013 Final Research Report
  • [Presentation] IgA腎症扁桃におけるAPRIL(A ProlifeRation-Inducing Ligand)の検討2012

    • Author(s)
      高原 幹、熊井 琢美、駒林 優樹、林 達哉、 原渕 保明
    • Organizer
      口腔・咽頭科
    • Place of Presentation
      熊本市
    • Related Report
      2012 Research-status Report
  • [Presentation] IgA腎症におけるAPRIL(A ProlifeRation-Inducing Ligand)の検討2012

    • Author(s)
      高原 幹、原渕 保明
    • Organizer
      日本腎臓学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 扁桃を中心としたIgA腎症の病態解明2011

    • Author(s)
      高原幹
    • Organizer
      IgA腎症扁摘パルス療法セミナー
    • Place of Presentation
      旭川
    • Year and Date
      2011-05-12
    • Related Report
      2013 Final Research Report
  • [Presentation] IgA腎症におけるAPRIL(A ProlifeRation-Inducing Ligand)の役割.2011

    • Author(s)
      高原幹, 他
    • Organizer
      第54回日本腎臓学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] IgA腎症におけるAPRIL(A ProlifeRation-Inducing Ligand)の役割2011

    • Author(s)
      高原 幹, 吉野和美, 長門利純, 岸部 幹, 原渕保明
    • Organizer
      第54回日本腎臓学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] IgA腎症におけるAPRIL(A ProlifeRation-Inducing Ligand)の検討2011

    • Author(s)
      高原 幹, 駒林優樹, 小林祐希, 長門利純, 岸部 幹, 原渕保明
    • Organizer
      第24回日本口腔・咽頭科学会
    • Place of Presentation
      広島
    • Related Report
      2011 Research-status Report
  • [Book] ENT臨床フロンティア「プライマリケアにおけるどの異常への対応」扁桃摘出術の適応は変わったか?2013

    • Author(s)
      高原幹
    • Publisher
      中山書店
    • Related Report
      2013 Final Research Report
  • [Book] ENT臨床フロンティア「口腔・咽頭疾患、歯牙疾患の臨床」扁桃病巣感染症の診断と手術適応2013

    • Author(s)
      高原幹
    • Publisher
      中山書店
    • Related Report
      2013 Final Research Report
  • [Book] ENT臨床フロンティア のどの異常とプライマリケア 扁桃摘出術の適応は変わったか?2013

    • Author(s)
      高原 幹
    • Total Pages
      262
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report
  • [Book] ENT臨床フロンティア 口腔・咽頭疾患、歯牙関連疾患を診る 扁桃病巣疾患の診断と手術適応2013

    • Author(s)
      高原 幹
    • Total Pages
      306
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report
  • [Book] ENT臨床フロンティア『プライマリケアにおけるのどの異常への対応』扁桃摘出術の適応は変わったか?2013

    • Author(s)
      高原幹
    • Total Pages
      6
    • Publisher
      中山書店
    • Related Report
      2012 Research-status Report
  • [Book] ENT臨床フロンティア『口腔・咽頭疾患、歯牙疾患の臨床』扁桃病巣感染症の診断と手術適応2013

    • Author(s)
      高原幹
    • Total Pages
      6
    • Publisher
      中山書店
    • Related Report
      2012 Research-status Report
  • [Remarks] 当科での業績が記載されています。

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/oto/

    • Related Report
      2013 Final Research Report
  • [Remarks] 旭川医科大学耳鼻咽喉科・頭頸部外科学教室ホームページ

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/oto/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi