A study on the role of Tropomyosin gene for cataractogenesis and the prevention of cataract
| Project/Area Number |
23592558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
KUBO Eri 金沢医科大学, 医学部, 教授 (10262619)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | トロポミオシン / 白内障 / 後嚢混濁 / 細胞分化 / 上皮間葉系移行 / 水晶体上皮細胞 / 後発白内障 / FGF2 / TGFβ2 / マイクロRNA |
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| Research Abstract |
Tropomyosin is an extracellular matrix protein related with differentiation of lens.Our study revealed that Tpm is related with the onset of human anterior subcapsular cataract and severe nuclear cataract. Further, Tpm was also related with the progression of posterior capsular opacity after cataract, which induces the impaired visual function.
From these results, Tpm may be an important gene related with lens differentiation and epithelial mesenchymal transition.
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Report
(4 results)
Research Products
(23 results)
