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Study of Pathological Mechanism in Light Induced Retinal Damage using DNA Base Excision Repair Gene Knockout Mice

Research Project

Project/Area Number 23592570
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionShimane University

Principal Investigator

OHIRA Akihiro  島根大学, 医学部, 教授 (00169054)

Co-Investigator(Kenkyū-buntansha) TANITO Masaki  島根大学, 医学部, 講師 (30284037)
KAIDZU Sachiko  島根大学, 医学部, 助教 (00325052)
NAKABEPPU Yusaku  九州大学, 生体防御医学研究所, 教授 (30180350)
OKUNO Tsutomu  労働安全衛生研究所, 人間工学・リスク研究グループ, 部長 (90332395)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords酸化ストレス / OGG1 / MUTYH / MTH1 / 網膜光障害 / OGG1 / MUTHY
Research Abstract

The present study aimed to elucidate the pathological mechanism in light induced retinal damage using 8-oxoguanine-DNA glycosylase (OGG1), human MutT Homolog 1 (MTH1) and MutY glycosylase homologue (MUTYH) knockout mice. Mice were exposed to 350-385 nm wavelengths light, and retinal radiant exposure was 75 J/cm2. Retinal light damage was reduced in MUTYH knockout mice, indicating that MUTYH involved in the pathological mechanism of light damage. Our results show the possibility that the suppression of neurodegeneration by control of MUTYH may effectively protect retinal light damage.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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