Molecular biological investigation for age-related macular degeneration and order made treatment
| Project/Area Number |
23592573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
YUJI Oshima 九州大学, 大学病院, 助教 (00536237)
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| Co-Investigator(Kenkyū-buntansha) |
SONODA Koh-hei 山口大学医学部, 眼科, 教授 (10294943)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 眼生化学 / 分子生物学 / 加齢黄斑変性 / 遺伝子多型 / 脈絡膜新生血管 / IL-27 |
|---|
| Research Abstract |
Age Related Macular Degeneration (AMD) is the main cause of legal blindness in the Western and Asian countries. The pathogenesis is the choroidal neovascularization (CNV) beneath the macula in the retina. The anti-VEGF therapy is the major treatment, but there still many intractable cases. We investigated the effectiveness of cytokines for CNV progression, and the correlation of genetic background and treatment effect to search new treatment. IL-27 was significantly reduced CNV progression by VEGF secretion blocking. And the injection of IL-17 blockage in CNV model mouse eye significantly reduced CNV progression. These cytokines are supposed to be one of the new treatment targets for AMD. Although we also investigated the correlation between some SNPs and the effectiveness of anti-VEGF therapy from clinical data, there aren't significantly differences between them for early treatment phase.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy2014
Author(s)
Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A, Kono T, Hafezi-Moghadam A, Ishibashi T.
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Journal Title
FASEB J
Volume: 28
Issue: 1
Pages: 131-142
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Involvement of Periostin in Regression of Hyaloidvascular System during Ocular Development.2012
Author(s)
Arima M, Yoshida S, Nakama T, Ishikawa K, Nakao S, Yoshimura T, Asato R, Sassa Y, Kita T, Enaida H, Oshima Y, Matsuda A, Kudo A, Ishibashi T.
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 53
Pages: 6495-503
Related Report
Peer Reviewed
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[Journal Article] Establishment of a new animal model of focal subretinal fibrosis that resembles disciform lesion in advanced age-related macular degeneration.2011
Author(s)
Jo YJ, Sonoda KH, Oshima Y, Takeda A, Kohno R, Yamada J, Hamuro J, Yang Y, Notomi S, Hisatomi T, Ishibashi T.
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52
Pages: 6089-95
Related Report
Peer Reviewed
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[Journal Article] Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.2011
Author(s)
Arakawa S, Takahashi A, Ashikawa K, Hosono N, Aoi T, Yasuda M, Oshima Y, Yoshida S, Enaida H, Tsuchihashi T, et al
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Journal Title
Nat Genet
Volume: 43
Pages: 1001-4
Related Report
Peer Reviewed
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