| Project/Area Number |
23592616
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Saitama Medical University (2013)
Keio University (2011-2012) |
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Principal Investigator |
YOSHIDA Tetsu 埼玉医科大学, 医学部, 助教 (00365438)
|
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| Co-Investigator(Kenkyū-buntansha) |
OZAWA Yoko 慶應義塾大学, 医学部, 講師 (90265885)
|
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 網膜色素変性症 / iPS細胞 / 再生医療 / 網膜 |
|---|
| Research Abstract |
Retinitis pigmentosa (RP) is a kind of neurodegenerative diseases, which causes degeneration of rod cells in retina. In this work, we analyzed the mechanisms of the rod cells death and screened reagents which inhibited the degeneration. First of all, we developed a iPS cell line from an RP patient which a rhodopsin mutation and then induced rod cell differentiation. The rod cells with a rhodopsin mutation had more apoptotic cells than the cells without rhodopsin mutations. Next, we found that a reagent called 'rapamycin' inhibited the cell death of the rod cells, indicating that prescribing rapamycin to RP patient, which were caused by rhodopsin mutations, could inhibit the progress of the conditions of the disease.
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