| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Though Trim16 is known to be expressed in epidermal tissue, and involved in KGF signaling, the precise molecular function is unknown. In this study, we analyzed the role of Trim16 in sunburn formation by UVB irradiation on skin. We found that deficiency in Trim16 leads to high sensitivity to UVB by using Trim16 knock down cells and knockout mouse. Our data suggested decrease in the anti-apoptotic protein level is related to this phenomenon, Trim16 has a role in regulation of apoptosis pathway.
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