| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We identified that the immunoreceptor MAIR-I (CD300a), which is expressed on myeloid cells including mast cells, is a phosphatidylserine (PS) receptor. We showed that MAIR-I does not facilitate macrophage phagocytosis of apoptotic cells, but rather inhibits the production of inflammatory cytokines and chemokines from mast cells that to recruit neutrophils to the peritoneal cavity to clear bacteria during murine sepsis model. We showed MAIR-I on mast cells and PS binding contributes to the survival of murine sepsis model.
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